Manteia - Molecule gene

ENSMUSG00000026602

Mus musculus

Features

Gene ID:	ENSMUSG00000026602

Biological name :	Nphs2

Synonyms :	Nphs2 / Podocin / Q91X05

Possible biological names infered from orthology :	NPHS2, podocin / Q9NP85

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	G3
Gene start:	156310727
Gene end:	156328035

Corresponding Affymetrix probe sets:	10350806 (MoGene1.0st) 1437605_at (Mouse Genome 430 2.0 Array) 1460297_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000027896 Ensembl peptide - ENSMUSP00000141328 NCBI entrez gene - 170484 See in Manteia. MGI - MGI:2157018 RefSeq - XM_006496683 RefSeq - XM_006496684 RefSeq - NM_130456 RefSeq Peptide - NP_569723 swissprot - Q91X05 swissprot - C0LL94 swissprot - A0A0A6YVZ4 Ensembl - ENSMUSG00000026602

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nphs2	ENSDARG00000042850	Danio rerio
NPHS2	ENSGALG00000004163	Gallus gallus
NPHS2	ENSG00000116218	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Stom / P54116 / Erythrocyte band 7 integral membrane protein / P27105* / stomatin*	ENSMUSG00000026880	37
Q6PE84 / Stoml3 / stomatin (Epb7.2)-like 3 / Q8TAV4* / stomatin like 3*	ENSMUSG00000027744	32
Stoml1 / stomatin like 1 / Q9UBI4*	ENSMUSG00000032333	21
Q99JB2 / Stoml2 / Stomatin-like protein 2, mitochondrial / Q9UJZ1* / stomatin like 2*	ENSMUSG00000028455	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR001107	Band 7 domain
IPR001972	Stomatin family
IPR028509	Podocin
IPR036013	Band 7/SPFH domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007588	excretion	IEA
biological_process	GO:0031532	actin cytoskeleton reorganization	IEA
biological_process	GO:0072249	metanephric glomerular visceral epithelial cell development	IEA
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0005887	integral component of plasma membrane	IEA
cellular_component	GO:0005911	cell-cell junction	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane	IDA
cellular_component	GO:0032991	protein-containing complex	IEA
cellular_component	GO:0036057	slit diaphragm	IDA
cellular_component	GO:0045121	membrane raft	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Nephrin family interactions

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000521	abnormal kidney cortex	"anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0000523	cortical glomerulopathies	"any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc
MP:0000533	kidney hemorrhage	"bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Stat5b^tm1Mam/Stat5b^tm1Mam,Tg(MMTV-cre)1Mam/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Stat5b^tm1Mam/Stat5b^tm1Mam,Tg(MMTV-cre)1Mam/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0002703	abnormal renal tubules	"anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0002705	dilated renal tubules	"enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0002828	abnormal glomerular capsule	"anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0002871	albuminuria	"presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0003215	renal interstitial fibrosis	"formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]	Show Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0003606	kidney failure	"cessation of renal function" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc
MP:0004154	renal tubular necrosis	"pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0004756	abnormal proximal convoluted tubule morphology	"any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0005264	glomerulosclerosis	"hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0005326	abnormal podocytes	"anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0006144	increased systolic blood pressure	"abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0008059	abnormal podocyte foot process morphology	"any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc
MP:0008061	absent podocyte slit diaphragm	"absence of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008140	podocyte foot process effacement	"thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0009050	dilated proximal convoluted tubules	"stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0009640	abnormal renal tubule epithelium morphology	"any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0011294	renal glomerulus hypertrophy	"increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0011309	abnormal kidney arterial blood vessel morphology	"any structural anomaly of the network of tubes that supply blood to the renal tissues" [MGI:csmith]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0011320	abnormal glomerular capillary morphology	"any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0011321	abnormal peritubular capillary morphology	"any structural anomaly of the tiny blood vessels that receive blood from the efferent arterioles of the glomerulus, and interact with superficial cortical nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron; peritubular capillaries are situated around the tubule and are at low pressure" [MGI:csmith]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0011346	renal tubule atrophy	"acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0011348	abnormal renal glomerulus basement membrane morphology	"any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0011353	expanded mesangial matrix	"increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0011402	renal cast	"any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0011427	mesangial cell hyperplasia	"increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]	Show Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA
MP:0011430	mesangiolysis	"an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0011453	abnormal glomerular capillary endothelium morphology	"any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0011454	abnormal glomerular endothelium fenestra morphology	"any structural anomaly of the large plasma membrane-lined circular pores that perforate the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, are not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes" [MGI:anna]	Show Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0011506	glomerular crescent	"formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]	Show Allelic Composition: Nphs2^tm1Antc/Nphs2^tm1Antc Genetic Background: 129-Nphs2^tm1Antc
MP:0011509	dilated glomerular capillary	"stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole" [MGI:anna]	Show Allelic Composition: Nphs2^tm2.1Antc/Nphs2^tm2.1Antc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0011868	podocyte microvillus transformation	"aberrant formation of numerous slender cellular projections resembling microvilli or vesicle-like structures along the apical surface of podocytes, suggestive of podocyte injury" [MGI:anna]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J
MP:0011871	podocyte hypertrophy	"increase in the bulk size of the modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle, due to cell enlargement" [MGI:anna]	Show Allelic Composition: Lep^ob/Lep^ob,Stxbp5l^T2dm1/Stxbp5l^T2dm1,T2dm2^C57BL/6J/T2dm2^C57BL/6J Genetic Background: involves: BTBR * C57BL/6J Allelic Composition: Nphs2^tm1Antc/Nphs2^tm3.1Antc,Tg(CAG-cre/Esr1)86Lbgn/0 Genetic Background:* involves: 129 * C57BL/6 * DBA

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000041734	Q80W68 / Kirrel / Kin of IRRE-like protein 1 / Q96J84* / KIRREL1* / kirre like nephrin family adhesion molecule 1*	/ complex / reaction
ENSMUSG00000019843	Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*	/ complex / reaction
ENSMUSG00000026602	Nphs2 / Q91X05 / Podocin / Q9NP85* / NPHS2, podocin*	/ -
ENSMUSG00000006649	Nphs1 / Q9QZS7 / Nephrin / O60500* / NPHS1, nephrin*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr