ENSG00000126266


Homo sapiens

Features
Gene ID: ENSG00000126266
  
Biological name :FFAR1
  
Synonyms : FFAR1 / free fatty acid receptor 1 / O14842
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.12
Gene start: 35351552
Gene end: 35353862
  
Corresponding Affymetrix probe sets: 1561507_at (Human Genome U133 Plus 2.0 Array)   231761_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000246553
NCBI entrez gene - 2864     See in Manteia.
OMIM - 603820
RefSeq - NM_005303
RefSeq Peptide - NP_005294
swissprot - O14842
Ensembl - ENSG00000126266
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-211g8.9ENSDARG00000087828Danio rerio
 Ffar1ENSMUSG00000044453Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPR42 / O15529 / G protein-coupled receptor 42 (gene/pseudogene)ENSG0000012625131
FFAR3 / O14843 / free fatty acid receptor 3ENSG0000018589731
FFAR2 / O15552 / free fatty acid receptor 2ENSG0000012626228
F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3ENSG0000012753322
GPR4 / P46093 / G protein-coupled receptor 4ENSG0000017746421
F2R / P25116 / coagulation factor II thrombin receptorENSG0000018110421
P2RY8 / Q86VZ1 / P2Y receptor family member 8ENSG0000018216221
GPR68 / Q15743 / G protein-coupled receptor 68ENSG0000011971421
F2RL1 / P55085 / F2R like trypsin receptor 1ENSG0000016425121
F2RL2 / O00254 / coagulation factor II thrombin receptor like 2ENSG0000016422018
GPR132 / Q9UNW8 / G protein-coupled receptor 132ENSG0000018348418
GPR65 / Q8IYL9 / G protein-coupled receptor 65ENSG0000014003015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR013312  G protein-coupled receptor 40-related receptor
 IPR013313  GPR40 receptor fatty acid
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IDA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070542 response to fatty acid IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0045125 bioactive lipid receptor activity IDA


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Free fatty acid receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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