ENSMUSG00000027611


Mus musculus

Features
Gene ID: ENSMUSG00000027611
  
Biological name :Procr
  
Synonyms : Procr / protein C receptor, endothelial / Q64695
  
Possible biological names infered from orthology : protein C receptor / Q9UNN8
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 155751117
Gene end: 155755471
  
Corresponding Affymetrix probe sets: 10477717 (MoGene1.0st)   1420664_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114567
Ensembl peptide - ENSMUSP00000029140
NCBI entrez gene - 19124     See in Manteia.
MGI - MGI:104596
RefSeq - NM_011171
RefSeq - XM_006498955
RefSeq Peptide - NP_035301
swissprot - A2AUV5
swissprot - Q64695
Ensembl - ENSMUSG00000027611
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PROCRENSGALG00000006547Gallus gallus
 PROCRENSG00000101000Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011161  MHC class I-like antigen recognition-like
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR015669  Endothelial protein C receptor
 IPR037055  MHC class I-like antigen recognition-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0050819 negative regulation of coagulation IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008022 protein C-terminus binding ISS


Pathways (from Reactome)
Pathway description
Common Pathway of Fibrin Clot Formation
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Procrtm1Cte/Procr+
Genetic Background: B6.129S7-Procrtm1Cte

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J

Allelic Composition: Procrtm1Cte/Procr+
Genetic Background: B6.129S7-Procrtm1Cte

Allelic Composition: Procrtm1.1Pcl/Procrtm1.1Pcl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Procrtm1.1Pcl/Procrtm1.1Pcl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Procrtm1.1Pcl/Procr+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Procrtm1.1Pcl/Procrtm1.1Pcl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Procrtm1.1Pcl/Procrtm1.1Pcl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Procrtm1.1Pcl/Procrtm1.1Pcl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Procrtm1.1Pcl/Procrtm1.1Pcl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010212 abnormal circulating C-reactive protein level "deviation from the normal levels of the plasma protein that circulates in increased amounts during inflammation or after tissue damage and binds to phosphocholine expressed on the surface of dead or dying cells, including all types of pneumococci, in order to activate the complement system via the C1Q complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D12.776.034.145, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J

 MP:0010213 abnormal circulating fibrinogen level "deviation from the normal levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J

Allelic Composition: F3tm1Dco/F3tm1Dco,Procrtm1Cte/Procrtm1Cte
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * Black Swiss * C57BL/6 * FVB/N

Allelic Composition: Procrtm1Cte/Procrtm1Cte,Tg(F3)1Nmk/0
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Procrtm3Cte/Procrtm3Cte
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Procrtm1Cte/Procrtm1Cte,Tg(Tek-Procr)1Cte/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Procrtm1.1(cre/ERT2)Yaz/Procrtm1.1(cre/ERT2)Yaz
Genetic Background: Not Specified

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: NntC57BL/6J/NntC57BL/6J
Genetic Background: C57BL/6J

 MP:0013776 bone marrow failure "inherited or acquired dysfunction of hematopoietic stem cells that can result in abnormalities in one or more of the stem cell lineages (erythroid, myeloid, megakaryocytic)" [http://emedicine.medscape.com/article/199003-overview, MGI:llw2]
Show

Allelic Composition: Procrtm1.1Pcl/Procrtm1.1Pcl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0020407 abnormal placental thrombosis "any anomaly in the formation or presence of a thrombus within the blood vessel network of the placenta" [MGI:anna]
Show

Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000024386 Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...  / complex / reaction
 ENSMUSG00000057729 Prtn3 / proteinase 3 / P24158*  / complex / reaction
 ENSMUSG00000048376 F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*  / reaction / complex
 ENSMUSG00000052212 Cd177 / Q8R2S8 / CD177 antigen / Q8N6Q3* / CD177 molecule*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr