ENSG00000008853


Homo sapiens

Features
Gene ID: ENSG00000008853
  
Biological name :RHOBTB2
  
Synonyms : Q9BYZ6 / RHOBTB2 / Rho related BTB domain containing 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.3
Gene start: 22987417
Gene end: 23020199
  
Corresponding Affymetrix probe sets: 1554586_a_at (Human Genome U133 Plus 2.0 Array)   209441_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430785
Ensembl peptide - ENSP00000251822
Ensembl peptide - ENSP00000427926
Ensembl peptide - ENSP00000429141
NCBI entrez gene - 23221     See in Manteia.
OMIM - 607352
RefSeq - XM_017013251
RefSeq - NM_001160036
RefSeq - NM_001160037
RefSeq - NM_015178
RefSeq Peptide - NP_001153508
RefSeq Peptide - NP_001153509
RefSeq Peptide - NP_055993
swissprot - Q9BYZ6
swissprot - E5RI44
Ensembl - ENSG00000008853
  
Related genetic diseases (OMIM): 618004 - Epileptic encephalopathy, early infantile, 64, 618004
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RHOBTB2ENSGALG00000034020Gallus gallus
 Q91V93ENSMUSG00000022075Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O94844 / RHOBTB1 / Rho related BTB domain containing 1ENSG0000007242264
RAC3 / P60763 / Rac family small GTPase 3ENSG0000016975011
RAC2 / P15153 / Rac family small GTPase 2ENSG0000012834011
RHOG / P84095 / ras homolog family member GENSG0000017710511
RAC1 / P63000 / Rac family small GTPase 1ENSG0000013623811
RHOU / Q7L0Q8 / ras homolog family member UENSG0000011657410
RHOV / Q96L33 / ras homolog family member VENSG0000010414010
RHOQ / P17081 / ras homolog family member QENSG0000011972910
CDC42 / P60953 / cell division cycle 42ENSG0000007083110
RHOJ / Q9H4E5 / ras homolog family member JENSG000001267859


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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