ENSG00000119729


Homo sapiens

Features
Gene ID: ENSG00000119729
  
Biological name :RHOQ
  
Synonyms : P17081 / ras homolog family member Q / RHOQ
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p21
Gene start: 46541806
Gene end: 46583121
  
Corresponding Affymetrix probe sets: 1559582_at (Human Genome U133 Plus 2.0 Array)   212117_at (Human Genome U133 Plus 2.0 Array)   212119_at (Human Genome U133 Plus 2.0 Array)   212120_at (Human Genome U133 Plus 2.0 Array)   212122_at (Human Genome U133 Plus 2.0 Array)   214449_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000238738
Ensembl peptide - ENSP00000428006
Ensembl peptide - ENSP00000428624
Ensembl peptide - ENSP00000429003
Ensembl peptide - ENSP00000393140
NCBI entrez gene - 23433     See in Manteia.
OMIM - 605857
RefSeq - XM_017003716
RefSeq - NM_012249
RefSeq - XM_011532726
RefSeq - XM_011532728
RefSeq Peptide - NP_036381
swissprot - P17081
swissprot - E5RFZ3
swissprot - F8WET9
swissprot - H0YB40
swissprot - H0YB93
swissprot - V9HWD0
Ensembl - ENSG00000119729
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhoqENSDARG00000025953Danio rerio
 RHOQENSGALG00000010010Gallus gallus
 RhoqENSMUSG00000024143Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RHOJ / Q9H4E5 / ras homolog family member JENSG0000012678576
CDC42 / P60953 / cell division cycle 42ENSG0000007083162
RAC1 / P63000 / Rac family small GTPase 1ENSG0000013623860
RAC3 / P60763 / Rac family small GTPase 3ENSG0000016975059
RAC2 / P15153 / Rac family small GTPase 2ENSG0000012834057
RHOG / P84095 / ras homolog family member GENSG0000017710551
RHOU / Q7L0Q8 / ras homolog family member UENSG0000011657450
RHOV / Q96L33 / ras homolog family member VENSG0000010414049
O94844 / RHOBTB1 / Rho related BTB domain containing 1ENSG0000007242237
Q9BYZ6 / RHOBTB2 / Rho related BTB domain containing 2ENSG0000000885336


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008286 insulin receptor signaling pathway IMP
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IC
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046039 GTP metabolic process IDA
 biological_processGO:0046326 positive regulation of glucose import IMP
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051491 positive regulation of filopodium assembly IDA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane TAS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005522 profilin binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0032427 GBD domain binding IPI


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Rho GTPase cycle
RHO GTPases regulate CFTR trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000047932 GOPC / Q9HD26 / golgi associated PDZ and coiled-coil motif containing  / complex / reaction
 ENSG00000001626 CFTR / P13569 / cystic fibrosis transmembrane conductance regulator  / reaction / complex






 

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