ENSG00000047932


Homo sapiens

Features
Gene ID: ENSG00000047932
  
Biological name :GOPC
  
Synonyms : golgi associated PDZ and coiled-coil motif containing / GOPC / Q9HD26
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q22.1
Gene start: 117560269
Gene end: 117602542
  
Corresponding Affymetrix probe sets: 225022_at (Human Genome U133 Plus 2.0 Array)   225023_at (Human Genome U133 Plus 2.0 Array)   227214_at (Human Genome U133 Plus 2.0 Array)   227215_at (Human Genome U133 Plus 2.0 Array)   236862_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357484
Ensembl peptide - ENSP00000052569
Ensembl peptide - ENSP00000445690
NCBI entrez gene - 57120     See in Manteia.
OMIM - 606845
RefSeq - NM_020399
RefSeq - NM_001017408
RefSeq Peptide - NP_001017408
RefSeq Peptide - NP_065132
swissprot - Q9HD26
swissprot - F5H1Y4
Ensembl - ENSG00000047932
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gopcENSDARG00000023117Danio rerio
 ENSGALG00000014902Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AL132671.2ENSG0000028221842
SNTB2 / Q13425 / syntrophin beta 2ENSG0000016880718
SNTB1 / Q13884 / syntrophin beta 1ENSG0000017216417
SNTA1 / Q13424 / syntrophin alpha 1ENSG0000010140016
SNTG2 / Q9NY99 / syntrophin gamma 2ENSG0000017255415
LIN7A / O14910 / lin-7 homolog A, crumbs cell polarity complex componentENSG0000011105213
SNTG1 / Q9NSN8 / syntrophin gamma 1ENSG0000014748113
LIN7B / Q9HAP6 / lin-7 homolog B, crumbs cell polarity complex componentENSG0000010486312
LIN7C / Q9NUP9 / lin-7 homolog C, crumbs cell polarity complex componentENSG0000014894312


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport NAS
 biological_processGO:0006893 Golgi to plasma membrane transport NAS
 biological_processGO:0010360 negative regulation of anion channel activity IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0043004 cytoplasmic sequestering of CFTR protein IMP
 biological_processGO:0045176 apical protein localization NAS
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051260 protein homooligomerization IPI
 biological_processGO:2000009 negative regulation of protein localization to cell surface IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle NAS
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044325 ion channel binding IPI


Pathways (from Reactome)
Pathway description
RHO GTPases regulate CFTR trafficking


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000001626 CFTR / P13569 / cystic fibrosis transmembrane conductance regulator  / complex
 ENSG00000047932 GOPC / Q9HD26 / golgi associated PDZ and coiled-coil motif containing  / complex
 ENSG00000119729 RHOQ / P17081 / ras homolog family member Q  / complex / reaction






 

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