ENSMUSG00000006519


Mus musculus

Features
Gene ID: ENSMUSG00000006519
  
Biological name :Cyba
  
Synonyms : Cyba / Cytochrome b-245 light chain / Q61462
  
Possible biological names infered from orthology : cytochrome b-245 alpha chain / P13498
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 122424776
Gene end: 122432930
  
Corresponding Affymetrix probe sets: 10582303 (MoGene1.0st)   1454268_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017604
Ensembl peptide - ENSMUSP00000148320
NCBI entrez gene - 13057     See in Manteia.
MGI - MGI:1316658
RefSeq - NM_001301284
RefSeq - NM_007806
RefSeq Peptide - NP_001288213
RefSeq Peptide - NP_031832
swissprot - Q61462
swissprot - B3VQI8
Ensembl - ENSMUSG00000006519
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cybaENSDARG00000018283Danio rerio
 CYBAENSGALG00000029367Gallus gallus
 CYBAENSG00000051523Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007732  Cytochrome b558 alpha-subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0003106 negative regulation of glomerular filtration by angiotensin IEA
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0014895 smooth muscle hypertrophy IEA
 biological_processGO:0017004 cytochrome complex assembly ISO
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0033864 positive regulation of NAD(P)H oxidase activity IEA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway ISO
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042554 superoxide anion generation IBA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045730 respiratory burst IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050665 hydrogen peroxide biosynthetic process IEA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IMP
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:0070257 positive regulation of mucus secretion IMP
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 biological_processGO:1900426 positive regulation of defense response to bacterium ISO
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process ISO
 biological_processGO:1904044 response to aldosterone IEA
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:1904845 cellular response to L-glutamine IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043020 NADPH oxidase complex ISO
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0097038 perinuclear endoplasmic reticulum IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009055 electron transfer activity ISO
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: 3110043O21Riktm1Lagi/3110043O21Riktm1Lagi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: 3110043O21Riktm1Lagi/3110043O21Riktm1Lagi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: 3110043O21Riktm1Lagi/3110043O21Riktm1Lagi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0002978 absent otoliths "absence of the crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: 3110043O21Riktm1Lagi/3110043O21Riktm1Lagi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: 3110043O21Riktm1Lagi/3110043O21Riktm1Lagi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003929 decreased heart rate variability "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]
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Allelic Composition: 3110043O21Riktm1Lagi/3110043O21Riktm1Lagi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: 3110043O21Riktm1Lagi/3110043O21Riktm1Lagi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004813 absent linear vestibular evoked potential "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: 3110043O21Riktm1Lagi/3110043O21Riktm1Lagi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
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Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: 3110043O21Riktm1Lagi/3110043O21Riktm1Lagi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0010697 abnormal systemic arterial blood pressure regulation "anomaly in the process that modulates the force with which blood travels through the systemic arterial circulatory system" [GO:0003073]
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Allelic Composition: 3110043O21Riktm1Lagi/3110043O21Riktm1Lagi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0013799 abnormal intestinal goblet cell physiology "any functional anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the small and large intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus; intestinal goblet cells produce a number of effector molecules including a range of mucins and antimicrobial proteins, such as trefoil factors and resistin-like molecules, which enable these to play a key part in innate defense mechanisms in the gut, against both bacterial and parasitic infections " [MGI:Anna, PMID:25872481]
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Allelic Composition: Dcbld2tm1Mhms/Dcbld2tm1.1Mhms,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015950 Ncf1 / Q09014 / Neutrophil cytosol factor 1 / P14598* / neutrophil cytosolic factor 1*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000019320 Noxo1 / Q8VCM2 / NADPH oxidase organizer 1 / Q8NFA2*  / complex
 ENSMUSG00000033220 Rac2 / Q05144 / Ras-related C3 botulinum toxin substrate 2 / P15153* / Rac family small GTPase 2*  / complex / reaction
 ENSMUSG00000015340 Cybb / Q61093 / Cytochrome b-245 heavy chain / P04839* / cytochrome b-245 beta chain*  / complex
 ENSMUSG00000031257 Nox1 / Q8CIZ9 / NADPH oxidase 1 / Q9Y5S8*  / complex
 ENSMUSG00000036805 Noxa1 / Q8CJ00 / NADPH oxidase activator 1 / Q86UR1*  / complex
 ENSMUSG00000026480 Ncf2 / O70145 / Neutrophil cytosol factor 2 / P19878* / neutrophil cytosolic factor 2*  / complex
 ENSMUSG00000023802 Nox3 / Q672J9 / NADPH oxidase 3 / Q9HBY0*  / complex
 ENSMUSG00000030562 Nox4 / Q9JHI8 / NADPH oxidase 4 / Q9NPH5*  / complex
 ENSMUSG00000071715 Ncf4 / P97369 / Neutrophil cytosol factor 4 / Q15080* / neutrophil cytosolic factor 4*  / complex






 

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