ENSMUSG00000015340


Mus musculus

Features
Gene ID: ENSMUSG00000015340
  
Biological name :Cybb
  
Synonyms : Cybb / Cytochrome b-245 heavy chain / Q61093
  
Possible biological names infered from orthology : cytochrome b-245 beta chain / P04839
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.1
Gene start: 9435252
Gene end: 9487771
  
Corresponding Affymetrix probe sets: 10603551 (MoGene1.0st)   1422978_at (Mouse Genome 430 2.0 Array)   1436778_at (Mouse Genome 430 2.0 Array)   1436779_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128963
Ensembl peptide - ENSMUSP00000128993
Ensembl peptide - ENSMUSP00000015484
NCBI entrez gene - 13058     See in Manteia.
MGI - MGI:88574
RefSeq - NM_007807
RefSeq - XM_006527565
RefSeq Peptide - NP_031833
swissprot - E9Q802
swissprot - Q3U6G0
swissprot - Q61093
swissprot - E9Q7S3
Ensembl - ENSMUSG00000015340
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cybbENSDARG00000056615Danio rerio
 CYBBENSGALG00000016261Gallus gallus
 CYBBENSG00000165168Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nox3 / Q672J9 / NADPH oxidase 3 / Q9HBY0*ENSMUSG0000002380256
Nox1 / Q8CIZ9 / NADPH oxidase 1 / Q9Y5S8*ENSMUSG0000003125755
Nox4 / Q9JHI8 / NADPH oxidase 4 / Q9NPH5*ENSMUSG0000003056237
Duox1 / dual oxidase 1 / Q9NRD9*ENSMUSG0000003326829
Duox2 / dual oxidase 2 / Q9NRD8*ENSMUSG0000006845228


Protein motifs (from Interpro)
Interpro ID Name
 IPR000778  Cytochrome b245, heavy chain
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IEA
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045730 respiratory burst IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0050665 hydrogen peroxide biosynthetic process IMP
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0097411 hypoxia-inducible factor-1alpha signaling pathway IEA
 biological_processGO:1904044 response to aldosterone IEA
 biological_processGO:1904845 cellular response to L-glutamine IEA
 biological_processGO:1990776 response to angiotensin IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gja10tm1Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cybbtm1Din/Cybbtm1Din
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cybbtm1Din/Cybbtm1Din
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002922 decreased post-tetanic potential "reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyb561tm1b(EUCOMM)Wtsi/Cyb561tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cyb561tm1b(EUCOMM)Wtsi/H

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005525 increased renal plasma flow rate "greater than the normal volume of plasma passing throught the kidney per unit time" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0005526 decreased renal plasma flow rate "less than the normal volume of plasma passing throught the kidney per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0005527 increased glomerular filtration rate "greater than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0005530 decreased renal vascular resistance "less than the normal force opposing blood flow in the kidney blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cybbtm1Din/Cybbtm1Din
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010759 decreased right ventricle systolic pressure "decrease in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cybbtm1Din/Cybbtm1Din
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011470 increased urine creatinine level "an increased amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

 MP:0011741 increased urine nitrite level "higher than normal amount of nitrite (NO2-) in the urine, usually indicative of a urinary tract infection; commonly a result of the action of Escherichia coli, Proteus vulgaris, and other microorganisms that may reduce nitrates" [MGI:anna]
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Allelic Composition: Cybbtm1Din/Y
Genetic Background: B6.129S-Cybbtm1Din

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015950 Ncf1 / Q09014 / Neutrophil cytosol factor 1 / P14598* / neutrophil cytosolic factor 1*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000026480 Ncf2 / O70145 / Neutrophil cytosol factor 2 / P19878* / neutrophil cytosolic factor 2*  / complex
 ENSMUSG00000033220 Rac2 / Q05144 / Ras-related C3 botulinum toxin substrate 2 / P15153* / Rac family small GTPase 2*  / reaction / complex
 ENSMUSG00000006519 Cyba / Q61462 / Cytochrome b-245 light chain / P13498* / cytochrome b-245 alpha chain*  / complex
 ENSMUSG00000030562 Nox4 / Q9JHI8 / NADPH oxidase 4 / Q9NPH5*  / complex
 ENSMUSG00000071715 Ncf4 / P97369 / Neutrophil cytosol factor 4 / Q15080* / neutrophil cytosolic factor 4*  / complex






 

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