ENSMUSG00000027805


Mus musculus

Features
Gene ID: ENSMUSG00000027805
  
Biological name :Pfn2
  
Synonyms : Pfn2 / Profilin-2 / Q9JJV2
  
Possible biological names infered from orthology : P35080
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: D
Gene start: 57841895
Gene end: 57848079
  
Corresponding Affymetrix probe sets: 10498309 (MoGene1.0st)   1418209_a_at (Mouse Genome 430 2.0 Array)   1418210_at (Mouse Genome 430 2.0 Array)   1436993_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112443
Ensembl peptide - ENSMUSP00000113526
Ensembl peptide - ENSMUSP00000068890
Ensembl peptide - ENSMUSP00000112391
NCBI entrez gene - 18645     See in Manteia.
MGI - MGI:97550
RefSeq - NM_019410
RefSeq Peptide - NP_062283
swissprot - D3YWS3
swissprot - Q9JJV2
Ensembl - ENSMUSG00000027805
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfn2lENSDARG00000012682Danio rerio
 PFN2ENSGALG00000010410Gallus gallus
 PFN2ENSG00000070087Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pfn1 / P62962 / profilin 1 / P07737*ENSMUSG0000001829362
Pfn3 / Q9DAD6 / Profilin-3 / P60673*ENSMUSG0000004444437
Gm45800ENSMUSG0000010985834


Protein motifs (from Interpro)
Interpro ID Name
 IPR005454  Profilin1/2/3, vertebrate
 IPR005455  Profilin
 IPR027310  Profilin conserved site
 IPR029891  Profilin-2
 IPR036140  Profilin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010633 negative regulation of epithelial cell migration IMP
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization ISO
 biological_processGO:0030838 positive regulation of actin filament polymerization ISO
 biological_processGO:0032233 positive regulation of actin filament bundle assembly ISO
 biological_processGO:0032781 positive regulation of ATPase activity ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0051496 positive regulation of stress fiber assembly ISO
 biological_processGO:1900028 negative regulation of ruffle assembly IMP
 biological_processGO:2000300 regulation of synaptic vesicle exocytosis IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0043195 terminal bouton IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISO
 molecular_functionGO:0016887 ATPase activity ISO


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pfn2tm1Wit/Pfn2tm1Wit,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Thrbtm1.1Syc/Thrbtm1.1Syc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000055805 Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*  / reaction / complex






 

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