ENSG00000070087


Homo sapiens

Features
Gene ID: ENSG00000070087
  
Biological name :PFN2
  
Synonyms : P35080 / PFN2 / profilin 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q25.1
Gene start: 149964904
Gene end: 150050788
  
Corresponding Affymetrix probe sets: 204992_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418494
Ensembl peptide - ENSP00000418521
Ensembl peptide - ENSP00000420504
Ensembl peptide - ENSP00000420417
Ensembl peptide - ENSP00000420244
Ensembl peptide - ENSP00000420202
Ensembl peptide - ENSP00000418523
Ensembl peptide - ENSP00000239940
Ensembl peptide - ENSP00000408283
Ensembl peptide - ENSP00000410464
Ensembl peptide - ENSP00000417351
Ensembl peptide - ENSP00000417817
Ensembl peptide - ENSP00000417912
Ensembl peptide - ENSP00000417924
Ensembl peptide - ENSP00000418142
Ensembl peptide - ENSP00000418216
NCBI entrez gene - 5217     See in Manteia.
OMIM - 176590
RefSeq - NM_053024
RefSeq - NM_002628
RefSeq Peptide - NP_002619
RefSeq Peptide - NP_444252
swissprot - C9J0J7
swissprot - F2Z3G0
swissprot - G5E9Q6
swissprot - C9JQ45
swissprot - P35080
swissprot - C9J712
swissprot - C9J5V8
swissprot - C9J2N0
Ensembl - ENSG00000070087
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfn2lENSDARG00000012682Danio rerio
 PFN2ENSGALG00000010410Gallus gallus
 Pfn2ENSMUSG00000027805Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PFN1 / P07737 / profilin 1ENSG0000010851861
PFN3 / P60673 / profilin 3ENSG0000019657040


Protein motifs (from Interpro)
Interpro ID Name
 IPR005454  Profilin1/2/3, vertebrate
 IPR005455  Profilin
 IPR027310  Profilin conserved site
 IPR029891  Profilin-2
 IPR036140  Profilin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010633 negative regulation of epithelial cell migration IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0032233 positive regulation of actin filament bundle assembly IMP
 biological_processGO:0032781 positive regulation of ATPase activity IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:1900028 negative regulation of ruffle assembly IEA
 biological_processGO:2000300 regulation of synaptic vesicle exocytosis IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0016887 ATPase activity IDA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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