ENSMUSG00000026785


Mus musculus

Features
Gene ID: ENSMUSG00000026785
  
Biological name :Pkn3
  
Synonyms : Pkn3 / Q8K045 / Serine/threonine-protein kinase N3
  
Possible biological names infered from orthology : protein kinase N3 / Q6P5Z2
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 30077684
Gene end: 30091022
  
Corresponding Affymetrix probe sets: 10470913 (MoGene1.0st)   1434525_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120268
Ensembl peptide - ENSMUSP00000041025
Ensembl peptide - ENSMUSP00000114492
NCBI entrez gene - 263803     See in Manteia.
MGI - MGI:2388285
RefSeq - XM_017318647
RefSeq - NM_153805
RefSeq - XM_006498052
RefSeq - XM_006498053
RefSeq - XM_006498054
RefSeq Peptide - NP_722500
swissprot - A2BE97
swissprot - A2BE96
swissprot - Q8K045
Ensembl - ENSMUSG00000026785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkn3ENSDARG00000079585Danio rerio
 PKN3ENSGALG00000004689Gallus gallus
 PKN3ENSG00000160447Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pkn2 / Q8BWW9 / Serine/threonine-protein kinase N2 / Q16513* / protein kinase N2*ENSMUSG0000000459152
Pkn1 / P70268 / Serine/threonine-protein kinase N1 / Q16512* / protein kinase N1*ENSMUSG0000005767251


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011072  HR1 rho-binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR035892  C2 domain superfamily
 IPR036274  HR1 repeat superfamily
 IPR037313  Serine/threonine-protein kinase N, first HR1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010631 epithelial cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017049 GTP-Rho binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases activate PKNs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pkn3tm1.1Mrl/Pkn3tm1.1Mrl,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkn3tm1.1Mrl/Pkn3tm1.1Mrl,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Pkn3tm1.1Mrl/Pkn3tm1.1Mrl,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atxn3tm1Hlp/Atxn3+
Genetic Background: involves: C57BL/6

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atxn3tm1Hlp/Atxn3+
Genetic Background: involves: C57BL/6

Allelic Composition: Pkn3tm1Ajmc/Pkn3tm1Ajmc
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Pkn1tm1Ajmc/Pkn1tm1Ajmc,Pkn3tm1Ajmc/Pkn3tm1Ajmc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NTac

Allelic Composition: Pkn1tm1Ajmc/Pkn1tm1Ajmc,Pkn2tm1a(KOMP)Wtsi/Pkn2+,Pkn3tm1Ajmc/Pkn3tm1Ajmc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * C57BL/6NTac

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pkn3tm1.1Mrl/Pkn3tm1.1Mrl,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

 MP:0010336 increased acute lymphoblastic leukemia incidence 
Show

Allelic Composition: Pkn3tm1.1Mrl/Pkn3tm1.1Mrl,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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