ENSMUSG00000031660


Mus musculus

Features
Gene ID: ENSMUSG00000031660
  
Biological name :Brd7
  
Synonyms : Brd7 / Bromodomain-containing protein 7 / O88665
  
Possible biological names infered from orthology : bromodomain containing 7 / Q9NPI1
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C3
Gene start: 88331039
Gene end: 88362194
  
Corresponding Affymetrix probe sets: 10580486 (MoGene1.0st)   1436469_at (Mouse Genome 430 2.0 Array)   1448521_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034085
NCBI entrez gene - 26992     See in Manteia.
MGI - MGI:1349766
RefSeq - XM_017312840
RefSeq - NM_012047
RefSeq - XM_006531048
RefSeq - XM_006531049
RefSeq - XM_006531046
RefSeq - XM_006531047
RefSeq Peptide - NP_036177
swissprot - O88665
Ensembl - ENSMUSG00000031660
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brd7ENSDARG00000008380Danio rerio
 BRD7ENSGALG00000003786Gallus gallus
 BRD7ENSG00000166164Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brd9 / Q3UQU0 / Bromodomain-containing protein 9 / Q9H8M2* / bromodomain containing 9*ENSMUSG0000005764931


Protein motifs (from Interpro)
Interpro ID Name
 IPR001487  Bromodomain
 IPR021900  Protein of unknown function DUF3512
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0035066 positive regulation of histone acetylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0070577 lysine-acetylated histone binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Acetylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prmt8tm1d(EUCOMM)Wtsi/Prmt8+
Genetic Background: involves: C57BL/6N

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0002800 abnormal short-term recognition memory "defects in the short-term memory for objects is established during the first few minutes after training" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prmt8tm1d(EUCOMM)Wtsi/Prmt8+
Genetic Background: involves: C57BL/6N

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prmt8tm1d(EUCOMM)Wtsi/Prmt8+
Genetic Background: involves: C57BL/6N

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0008821 increased blood uric acid level "greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Prmt8tm1d(EUCOMM)Wtsi/Prmt8+
Genetic Background: involves: C57BL/6N

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0012531 delayed limb development "late onset of the induction and/or differentiation of the limbs" [MGI:anna]
Show

Allelic Composition: Prmt8tm1d(EUCOMM)Wtsi/Prmt8+
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction / complex






 

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