ENSMUSG00000014905


Mus musculus

Features
Gene ID: ENSMUSG00000014905
  
Biological name :Dnajb9
  
Synonyms : Dnajb9 / DnaJ homolog subfamily B member 9 / Q9QYI6
  
Possible biological names infered from orthology : DnaJ heat shock protein family (Hsp40) member B9 / Q9UBS3
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: B2
Gene start: 44205559
Gene end: 44210326
  
Corresponding Affymetrix probe sets: 10400137 (MoGene1.0st)   1417191_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152011
Ensembl peptide - ENSMUSP00000015049
NCBI entrez gene - 27362     See in Manteia.
MGI - MGI:1351618
RefSeq - NM_013760
RefSeq Peptide - NP_038788
swissprot - A0A1W2P8C3
swissprot - Q9QYI6
Ensembl - ENSMUSG00000014905
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnajb9aENSDARG00000052072Danio rerio
 dnajb9bENSDARG00000016886Danio rerio
 DNAJB9ENSGALG00000009492Gallus gallus
 DNAJB9ENSG00000128590Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnajb5 / O89114 / Mus musculus DnaJ heat shock protein family (Hsp40) member B5 (Dnajb5), transcript variant 3, mRNA. / O75953* / DnaJ heat shock protein family (Hsp40) member B5*ENSMUSG0000003605232
Dnajb4 / Q9D832 / DnaJ homolog subfamily B member 4 / Q9UDY4* / DnaJ heat shock protein family (Hsp40) member B4*ENSMUSG0000002803528
Dnajb2 / Q9QYI5 / DnaJ homolog subfamily B member 2 / P25686* / DnaJ heat shock protein family (Hsp40) member B2*ENSMUSG0000002620327
Dnajb1 / Q9QYJ3 / DnaJ homolog subfamily B member 1 / P25685* / DnaJ heat shock protein family (Hsp40) member B1*ENSMUSG0000000548327
Dnajb6 / O54946 / DnaJ homolog subfamily B member 6 ENSMUSG0000002913127
Q80Y75 / Dnajb13 / DnaJ homolog subfamily B member 13 / P59910* / DnaJ heat shock protein family (Hsp40) member B13*ENSMUSG0000003070826
Dnajb8 / Q9QYI7 / DnaJ homolog subfamily B member 8 / Q8NHS0* / DnaJ heat shock protein family (Hsp40) member B8*ENSMUSG0000004820623
Dnajb3ENSMUSG0000008198423
4930503B20Rik / RIKEN cDNA 4930503B20 geneENSMUSG0000009020220
Dnajb7 / Q9QYI8 / DnaJ homolog subfamily B member 7 / Q7Z6W7* / DnaJ heat shock protein family (Hsp40) member B7*ENSMUSG0000004710819


Protein motifs (from Interpro)
Interpro ID Name
 IPR001623  DnaJ domain
 IPR018253  DnaJ domain, conserved site
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002377 immunoglobulin production IMP
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:1903895 negative regulation of IRE1-mediated unfolded protein response ISS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030544 Hsp70 protein binding IPI
 molecular_functionGO:0051087 chaperone binding IDA
 molecular_functionGO:0051787 misfolded protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg,Tg(CAG-XBP1*/Venus)#Miur/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0005216 abnormal pancreatic alpha cell morphology "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg,Tg(CAG-XBP1*/Venus)#Miur/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg,Tg(CAG-XBP1*/Venus)#Miur/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg,Tg(CAG-XBP1*/Venus)#Miur/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009160 abnormal pancreatic acinar cell zymogen granule "any structural anomaly of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg,Tg(CAG-XBP1*/Venus)#Miur/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg,Tg(CAG-XBP1*/Venus)#Miur/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg
Genetic Background: B6.129P2-Dnajb9Gt(KST256)Byg

 MP:0014117 increased pancreatic beta cell apoptosis "increase in the number of pancreatic beta cells undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Dnajb9Gt(KST256)Byg/Dnajb9Gt(KST256)Byg,Tg(CAG-XBP1*/Venus)#Miur/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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