ENSMUSG00000033249


Mus musculus

Features
Gene ID: ENSMUSG00000033249
  
Biological name :Hsf4
  
Synonyms : Heat shock factor protein 4 / Hsf4 / Q9R0L1
  
Possible biological names infered from orthology : heat shock transcription factor 4 / Q9ULV5
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 105269801
Gene end: 105275845
  
Corresponding Affymetrix probe sets: 10574659 (MoGene1.0st)   1425786_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134477
Ensembl peptide - ENSMUSP00000134206
Ensembl peptide - ENSMUSP00000134213
Ensembl peptide - ENSMUSP00000048904
Ensembl peptide - ENSMUSP00000126278
Ensembl peptide - ENSMUSP00000133532
Ensembl peptide - ENSMUSP00000133879
NCBI entrez gene - 26386     See in Manteia.
MGI - MGI:1347058
RefSeq - XM_017312837
RefSeq - NM_001256042
RefSeq - NM_001256044
RefSeq - NM_011939
RefSeq - XM_006531038
RefSeq - XM_006531039
RefSeq - XM_006531040
RefSeq - XM_006531041
RefSeq - XM_006531042
RefSeq Peptide - NP_001242973
RefSeq Peptide - NP_036069
RefSeq Peptide - NP_001242971
swissprot - G3UYS8
swissprot - G3UZF5
swissprot - G3UX32
swissprot - Q3UG93
swissprot - Q9R0L1
swissprot - B2RQY2
swissprot - G3UXZ1
Ensembl - ENSMUSG00000033249
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsf4ENSDARG00000013251Danio rerio
 HSF4ENSGALG00000003224Gallus gallus
 HSF4ENSG00000102878Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*ENSMUSG0000002255634
Hsf2 / P38533 / Heat shock factor protein 2 / Q03933* / heat shock transcription factor 2*ENSMUSG0000001987824
Hsf3ENSMUSG0000004580219


Protein motifs (from Interpro)
Interpro ID Name
 IPR000232  Heat shock factor (HSF)-type, DNA-binding
 IPR027725  Heat shock transcription factor family
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001654 eye development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0033169 histone H3-K9 demethylation IDA
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048468 cell development IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0070207 protein homotrimerization IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0019903 protein phosphatase binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hsf4tm1Miv/Hsf4tm1Miv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Gfi1tm2Tmo/Gfi1tm2Tmo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hsf4tm1Miv/Hsf4tm1Miv
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Hsf4tm1Miv/Hsf4tm1Miv
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk,Crygsrncat/Crygs+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Kunming

Allelic Composition: Hsf4ldis1/Hsf4ldis1
Genetic Background: involves: C57BL/6 * CAST/EiJ * RIIIS/J

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0001309 hydropic eye lens fibers "swollen cortical fibers of the eye lens" [J:14285]
Show

Allelic Composition: Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hsf4tm1Miv/Hsf4tm1Miv
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Hsf4tm1Xyk/Hsf4tm1Xyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003236 abnormal lens capsule morphology "malformation in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0005263 ectopia lentis "congenital displacement of the lens due to defective zonule formation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0008841 ruptured lens capsule "a break or tear in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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