ENSMUSG00000053395


Mus musculus

Features
Gene ID: ENSMUSG00000053395
  
Biological name :Cacng8
  
Synonyms : Cacng8 / voltage-dependent calcium channel gamma-8 subunit
  
Possible biological names infered from orthology : calcium voltage-gated channel auxiliary subunit gamma 8 / Q8WXS5
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A1
Gene start: 3390683
Gene end: 3415648
  
Corresponding Affymetrix probe sets: 10569702 (MoGene1.0st)   1451864_at (Mouse Genome 430 2.0 Array)   1459579_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138618
Ensembl peptide - ENSMUSP00000145502
Ensembl peptide - ENSMUSP00000090005
NCBI entrez gene - 81905     See in Manteia.
MGI - MGI:1932376
RefSeq - NM_133190
RefSeq Peptide - NP_573453
swissprot - A0A0N4SWF8
swissprot - F7CZ64
Ensembl - ENSMUSG00000053395
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacng8aENSDARG00000020450Danio rerio
 cacng8bENSDARG00000070626Danio rerio
 CACNG8ENSG00000142408Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cacng4 / Q9JJV4 / Voltage-dependent calcium channel gamma-4 subunit / Q9UBN1* / calcium voltage-gated channel auxiliary subunit gamma 4*ENSMUSG0000002072349
Cacng2 / O88602 / Voltage-dependent calcium channel gamma-2 subunit / Q9Y698* / calcium voltage-gated channel auxiliary subunit gamma 2*ENSMUSG0000001914646
Cacng3 / Q9JJV5 / Voltage-dependent calcium channel gamma-3 subunit / O60359* / calcium voltage-gated channel auxiliary subunit gamma 3*ENSMUSG0000006618944
Cacng7 / P62956 / Voltage-dependent calcium channel gamma-7 subunit / P62955* / calcium voltage-gated channel auxiliary subunit gamma 7*ENSMUSG0000006980620
Cacng5 / Q8VHW4 / Voltage-dependent calcium channel gamma-5 subunit / Q9UF02* / calcium voltage-gated channel auxiliary subunit gamma 5*ENSMUSG0000004037320


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR008368  Voltage-dependent calcium channel, gamma subunit
 IPR008372  Voltage-dependent calcium channel, gamma-8 subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA


Pathways (from Reactome)
Pathway description
Trafficking of AMPA receptors
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt1tm1Mrc/Wnt1tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac5tm1Eno/Hdac5tm1Eno,Tg(Myh6-Camta2)1Eno/0
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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