ENSG00000188747


Homo sapiens

Features
Gene ID: ENSG00000188747
  
Biological name :NOXA1
  
Synonyms : NADPH oxidase activator 1 / NOXA1 / Q86UR1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q34.3
Gene start: 137423350
Gene end: 137434406
  
Corresponding Affymetrix probe sets: 232373_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000342848
Ensembl peptide - ENSP00000376562
NCBI entrez gene - 10811     See in Manteia.
OMIM - 611255
RefSeq - XM_017014220
RefSeq - NM_001256067
RefSeq - NM_001256068
RefSeq - NM_006647
RefSeq - XM_011518158
RefSeq - XM_011518159
RefSeq - XM_011518160
RefSeq Peptide - NP_001242996
RefSeq Peptide - NP_001242997
RefSeq Peptide - NP_006638
swissprot - Q86UR1
Ensembl - ENSG00000188747
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 noxa1ENSDARG00000056047Danio rerio
 NOXA1ENSGALG00000008952Gallus gallus
 Noxa1ENSMUSG00000036805Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCF2 / P19878 / neutrophil cytosolic factor 2ENSG0000011670131


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR001452  SH3 domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR034899  NADPH oxidase activator 1
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IMP
 biological_processGO:0010310 regulation of hydrogen peroxide metabolic process IMP
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0060263 regulation of respiratory burst IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043020 NADPH oxidase complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IMP
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0048365 Rac GTPase binding IPI


Pathways (from Reactome)
Pathway description
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000007952 NOX1 / Q9Y5S8 / NADPH oxidase 1  / complex
 ENSG00000051523 CYBA / P13498 / cytochrome b-245 alpha chain  / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000074771 NOX3 / Q9HBY0 / NADPH oxidase 3  / complex
 ENSG00000158517 NCF1 / P14598 / neutrophil cytosolic factor 1  / complex
 ENSG00000196408 NOXO1 / Q8NFA2 / NADPH oxidase organizer 1  / complex






 

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