ENSDARG00000096666


Danio rerio

Features
Gene ID: ENSDARG00000096666
  
Biological name :si:ch211-1f22.2
  
Synonyms : si:ch211-1f22.2
  
Possible biological names infered from orthology : P63000 / P63001 / RAC1 / Rac family small GTPase 1 / RAS-related C3 botulinum substrate 1
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 56950797
Gene end: 56951369
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000126851
swissprot - R4GED8
ZFIN ID - ZDB-GENE-121214-149
Ensembl - ENSDARG00000096666
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAC1ENSGALG00000007130Gallus gallus
 RAC1ENSG00000136238Homo sapiens
 Rac1ENSMUSG00000001847Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch211-1f22.1 / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000001320368
rac1l / Rac family small GTPase 1, like / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000005464967
rac1b / Rac family small GTPase 1b / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000008795464
rac1a / Rac family small GTPase 1a / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000007484964
rac3a / Rac family small GTPase 3a / RAC3* / P60763* / Rac family small GTPase 3*ENSDARG0000009006263
rac2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *ENSDARG0000003801062
rac1l / si:ch73-94k4.2 / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*ENSDARG0000009654962
rac3b / Rac family small GTPase 3b / RAC3* / P60764* / P60763* / Rac family small GTPase 3* / RAS-related C3 botulinum substrate 3*ENSDARG0000002079562
cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *ENSDARG0000004457358
cdc42l / cell division cycle 42, likeENSDARG0000004015856
rhogd / ras homolog gene family, member GdENSDARG0000003060853
rhogc / ras homolog gene family, member GcENSDARG0000002840152
rhogb / ras homolog family member Gb / RHOG* / P84095* / P84096* / ras homolog family member G*ENSDARG0000000430152
rhoga / ras homolog family member Ga / RHOG* / P84095* / P84096* / ras homolog family member G*ENSDARG0000006865351
rhoq / ras homolog family member Q / P17081* / Q8R527* / Rho-related GTP-binding protein RhoQ *ENSDARG0000002595350
cdc42l2 / cell division cycle 42 like 2ENSDARG0000005786947
rhoj / ras homolog family member J / Q9ER71* / Q9H4E5*ENSDARG0000002025047
rhoua / ras homolog family member Ua / RHOU* / Q9EQT3* / Q7L0Q8* / ras homolog family member U* / Rho-related GTP-binding protein RhoU *ENSDARG0000001970946
rhov / ras homolog family member V / Q8VDU1* / Q96L33* / Rho-related GTP-binding protein RhoV *ENSDARG0000007043445
rhoub / ras homolog family member UbENSDARG0000001296843


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
NRAGE signals death through JNK
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
PCP/CE pathway
G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
Signal transduction by L1
VEGFR2 mediated vascular permeability
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate NADPH Oxidases
MAPK6/MAPK4 signaling
Neutrophil degranulation
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
NTRK2 activates RAC1
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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