Manteia

ENSDARG00000074849

Danio rerio

Features

Gene ID:	ENSDARG00000074849

Biological name :	rac1a

Synonyms :	rac1a / Rac family small GTPase 1a

Possible biological names infered from orthology :	P63000 / P63001 / RAC1 / Rac family small GTPase 1 / RAS-related C3 botulinum substrate 1

Species:	Danio rerio

Chr. number:	12
Strand:	-1
Band:
Gene start:	10464897
Gene end:	10476448

Corresponding Affymetrix probe sets:	Dr.4711.1.S1_at (Zebrafish Array) NM_199771_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000096950 NCBI entrez gene - 327204 See in Manteia. RefSeq - NM_199771 RefSeq Peptide - NP_956065 swissprot - Q7ZSZ9 ZFIN ID - ZDB-GENE-030131-5415 Ensembl - ENSDARG00000074849

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
RAC1	ENSGALG00000007130	Gallus gallus
RAC1	ENSG00000136238	Homo sapiens
Rac1	ENSMUSG00000001847	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
rac1b / Rac family small GTPase 1b / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*	ENSDARG00000087954	97
rac3b / Rac family small GTPase 3b / RAC3* / P60764* / P60763* / Rac family small GTPase 3* / RAS-related C3 botulinum substrate 3*	ENSDARG00000020795	95
rac3a / Rac family small GTPase 3a / RAC3* / P60763* / Rac family small GTPase 3*	ENSDARG00000090062	94
rac2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *	ENSDARG00000038010	92
cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *	ENSDARG00000044573	70
si:ch211-1f22.1 / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*	ENSDARG00000013203	70
rhogd / ras homolog gene family, member Gd	ENSDARG00000030608	69
rhogc / ras homolog gene family, member Gc	ENSDARG00000028401	69
cdc42l / cell division cycle 42, like	ENSDARG00000040158	69
rac1l / Rac family small GTPase 1, like / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*	ENSDARG00000054649	68
rhogb / ras homolog family member Gb / RHOG* / P84095* / P84096* / ras homolog family member G*	ENSDARG00000004301	67
rhoga / ras homolog family member Ga / RHOG* / P84095* / P84096* / ras homolog family member G*	ENSDARG00000068653	67
rhoq / ras homolog family member Q / P17081* / Q8R527* / Rho-related GTP-binding protein RhoQ *	ENSDARG00000025953	65
si:ch211-1f22.2 / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*	ENSDARG00000096666	64
rhoj / ras homolog family member J / Q9ER71* / Q9H4E5*	ENSDARG00000020250	63
rac1l / si:ch73-94k4.2 / RAC1* / P63001* / P63000* / Rac family small GTPase 1* / RAS-related C3 botulinum substrate 1*	ENSDARG00000096549	61
rhoua / ras homolog family member Ua / RHOU* / Q9EQT3* / Q7L0Q8* / ras homolog family member U* / Rho-related GTP-binding protein RhoU *	ENSDARG00000019709	55
cdc42l2 / cell division cycle 42 like 2	ENSDARG00000057869	55
RHOU (1 of many) / si:ch211-133l11.10 / RHOU* / Q9EQT3* / Q7L0Q8* / ras homolog family member U* / Rho-related GTP-binding protein RhoU *	ENSDARG00000005626	51
rhoub / ras homolog family member Ub	ENSDARG00000012968	51

Protein motifs (from Interpro)

Interpro ID	Name
IPR001806	Small GTPase superfamily
IPR003578	Small GTPase superfamily, Rho type
IPR005225	Small GTP-binding protein domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007264	small GTPase mediated signal transduction	IEA
biological_process	GO:0007520	myoblast fusion	IMP
biological_process	GO:0030593	neutrophil chemotaxis	IGI
biological_process	GO:0042074	cell migration involved in gastrulation	IGI
cellular_component	GO:0005622	intracellular	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003924	GTPase activity	IEA
molecular_function	GO:0005525	GTP binding	IEA

Pathways (from Reactome)

Pathway description

GPVI-mediated activation cascade

NRAGE signals death through JNK

Rho GTPase cycle

Regulation of actin dynamics for phagocytic cup formation

DAP12 signaling

FCERI mediated MAPK activation

CD28 dependent Vav1 pathway

EPHB-mediated forward signaling

Ephrin signaling

EPH-ephrin mediated repulsion of cells

Sema3A PAK dependent Axon repulsion

PCP/CE pathway

G alpha (12/13) signalling events

Sema4D mediated inhibition of cell attachment and migration

DCC mediated attractive signaling

VEGFA-VEGFR2 Pathway

Signal transduction by L1

VEGFR2 mediated vascular permeability

RHO GTPases activate PKNs

RHO GTPases activate CIT

RHO GTPases activate KTN1

RHO GTPases activate IQGAPs

RHO GTPases activate PAKs

RHO GTPases Activate WASPs and WAVEs

RHO GTPases Activate Formins

RHO GTPases Activate NADPH Oxidases

MAPK6/MAPK4 signaling

Neutrophil degranulation

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

MET activates RAP1 and RAC1

NTRK2 activates RAC1

Factors involved in megakaryocyte development and platelet production

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000114	heart	heart bilateral symmetry , abnormal	Show
ZFA:0009369	fast muscle myoblast	fast muscle myoblast unfused from fast muscle myoblast , abnormal fast muscle myoblast binucleate , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr