ENSDARG00000040812


Danio rerio

Features
Gene ID: ENSDARG00000040812
  
Biological name :ncf4
  
Synonyms : ncf4 / neutrophil cytosolic factor 4
  
Possible biological names infered from orthology : Neutrophil cytosol factor 4 / P97369 / Q15080
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 29204885
Gene end: 29252049
  
Corresponding Affymetrix probe sets: Dr.12333.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000059819
Ensembl peptide - ENSDARP00000122688
NCBI entrez gene - 403014     See in Manteia.
RefSeq - NM_205711
RefSeq Peptide - NP_991274
swissprot - Q1LUW2
swissprot - Q1LUW3
ZFIN ID - ZDB-GENE-041124-1
Ensembl - ENSDARG00000040812
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCF4ENSGALG00000038141Gallus gallus
 NCF4ENSG00000100365Homo sapiens
 Ncf4ENSMUSG00000071715Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000919  Neutrophil cytosol factor P40
 IPR001452  SH3 domain
 IPR001683  Phox homologous domain
 IPR034853  Neutrophil cytosol factor P40, PB1 domain
 IPR034912  Neutrophil cytosol factor 4, PX domain
 IPR035541  Neutrophil cytosol factor P40, SH3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0016192 vesicle-mediated transport IBA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045730 respiratory burst IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005802 trans-Golgi network IBA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IBA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018283 cyba / cytochrome b-245, alpha polypeptide / P13498* / cytochrome b-245 alpha chain*  / complex
 ENSDARG00000038010 rac2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *  / reaction / complex
 ENSDARG00000005821 ncf2 / neutrophil cytosolic factor 2 / O70145* / P19878* / Neutrophil cytosol factor 2 *  / complex
 ENSDARG00000056615 cybb / cytochrome b-245, beta polypeptide (chronic granulomatous disease) / Q61093* / P04839* / cytochrome b-245 beta chain* / Cytochrome b-245 heavy chain *  / complex






 

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