ENSDARG00000005821


Danio rerio

Features
Gene ID: ENSDARG00000005821
  
Biological name :ncf2
  
Synonyms : ncf2 / neutrophil cytosolic factor 2
  
Possible biological names infered from orthology : Neutrophil cytosol factor 2 / O70145 / P19878
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 41329748
Gene end: 41338923
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000089913
NCBI entrez gene - 562473     See in Manteia.
swissprot - A2VCY2
ZFIN ID - ZDB-GENE-070209-29
Ensembl - ENSDARG00000005821
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCF2ENSGALG00000004700Gallus gallus
 NCF2ENSG00000116701Homo sapiens
 Ncf2ENSMUSG00000026480Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
noxa1 / NADPH oxidase activator 1 / Q86UR1* / Q8CJ00*ENSDARG0000005604718


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR034885  Neutrophil cytosol factor 2, PB1 domain
 IPR034889  Neutrophil cytosol factor 2
 IPR035546  Neutrophil cytosol factor 2, SH3 domain 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045730 respiratory burst IEA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018283 cyba / cytochrome b-245, alpha polypeptide / P13498* / cytochrome b-245 alpha chain*  / complex
 ENSDARG00000038010 rac2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *  / reaction / complex
 ENSDARG00000040812 ncf4 / neutrophil cytosolic factor 4 / P97369* / Q15080* / Neutrophil cytosol factor 4 *  / complex
 ENSDARG00000056615 cybb / cytochrome b-245, beta polypeptide (chronic granulomatous disease) / Q61093* / P04839* / cytochrome b-245 beta chain* / Cytochrome b-245 heavy chain *  / complex






 

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