ENSGALG00000006522


Gallus gallus

Features
Gene ID: ENSGALG00000006522
  
Biological name :HCK
  
Synonyms : HCK / HCK proto-oncogene, Src family tyrosine kinase
  
Possible biological names infered from orthology : P08103 / P08631 / Tyrosine-protein kinase HCK
  
Species: Gallus gallus
  
Chr. number: 20
Strand: 1
Band:
Gene start: 10307594
Gene end: 10313413
  
Corresponding Affymetrix probe sets: Gga.6866.1.S1_at (Chicken Array)   Gga.8104.1.S1_at (Chicken Array)   GgaAffx.21963.1.S1_at (Chicken Array)   GgaAffx.21963.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000010524
NCBI entrez gene - 419280     See in Manteia.
RefSeq - XM_004947170
RefSeq - XM_015296447
RefSeq - XM_015296448
RefSeq - XM_015296449
RefSeq - XM_015296450
RefSeq - XM_015296451
RefSeq - XM_004947168
swissprot - E1BXA3
Ensembl - ENSGALG00000006522
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hckENSDARG00000058647Danio rerio
 HCKENSG00000101336Homo sapiens
 HckENSMUSG00000003283Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*ENSGALG0000004232169
LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *ENSGALG0000000046667
BLK / BLK proto-oncogene, Src family tyrosine kinase / P16277* / P51451* / Tyrosine-protein kinase Blk *ENSGALG0000001666162
YES1 / P09324 / Tyrosine-protein kinase Yes / Q04736* / P07947* / YES proto-oncogene 1, Src family tyrosine kinase*ENSGALG0000001486061
FGR / Q02977 / Proto-oncogene tyrosine-protein kinase Yrk ENSGALG0000003219961
SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*ENSGALG0000000385560
FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*ENSGALG0000001502258
FRK / fyn related Src family tyrosine kinase / P42685* / Q922K9* / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA.*ENSGALG0000001497949
SRMS / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / Q9H3Y6*ENSGALG0000000585238


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
FCGR activation
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr