ENSDARG00000056623


Danio rerio

Features
Gene ID: ENSDARG00000056623
  
Biological name :ptenb
  
Synonyms : phosphatase and tensin homolog B / ptenb
  
Possible biological names infered from orthology : O08586 / P60484 / phosphatase and tensin homolog / PTEN
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 17399852
Gene end: 17424174
  
Corresponding Affymetrix probe sets: Dr.5559.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000073594
Ensembl peptide - ENSDARP00000073600
NCBI entrez gene - 368415     See in Manteia.
swissprot - Q6TGR5
swissprot - Q7ZZ56
ZFIN ID - ZDB-GENE-030616-47
Ensembl - ENSDARG00000056623
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTENENSGALG00000003634Gallus gallus
 PTENENSG00000171862Homo sapiens
 PtenENSMUSG00000013663Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptena / phosphatase and tensin homolog A / PTEN* / O08586* / P60484* / phosphatase and tensin homolog*ENSDARG0000007101887
tpte / transmembrane phosphatase with tensin homology / TPTE2* / Q6XPS3* / P56180* / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2*ENSDARG0000005698528
tns2a / tensin 2a / TNS2* / Q63HR2* / Q8CGB6* / tensin 2* / Mus musculus tensin 2 (Tns2), transcript variant 2, mRNA.*ENSDARG0000007629227
tns1b / tensin 1b / TNS1* / Q9HBL0* / tensin 1*ENSDARG0000002084525
tns2b / tensin 2b / TNS2* / Q63HR2* / Q8CGB6* / tensin 2* / Mus musculus tensin 2 (Tns2), transcript variant 2, mRNA.*ENSDARG0000006839725
tns1a / tensin 1a / TNS1* / Q9HBL0* / tensin 1*ENSDARG0000007884224
dnajc6 / DnaJ (Hsp40) homolog, subfamily C, member 6 / O75061* / Q80TZ3* / DnaJ heat shock protein family (Hsp40) member C6*ENSDARG0000007989121
gak / cyclin G associated kinase / O14976* / cyclin-G-associated kinase isoform 3 *ENSDARG0000009065420
tns3.1 / tensin 3, tandem duplicate 1ENSDARG0000009565417
tns3.2 / tensin 3, tandem duplicate 2 / TNS3* / Q5SSZ5* / Q68CZ2* / tensin 3*ENSDARG000000319118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR014020  Tensin phosphatase, C2 domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR017361  Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0002275 myeloid cell activation involved in immune response IGI
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IGI
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031174 lifelong otolith mineralization IMP
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0046855 inositol phosphate dephosphorylation IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IMP
 biological_processGO:0051895 negative regulation of focal adhesion assembly IEA
 biological_processGO:0051896 regulation of protein kinase B signaling IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 biological_processGO:0061515 myeloid cell development IGI
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042577 lipid phosphatase activity IMP
 molecular_functionGO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Negative regulation of the PI3K/AKT network
Downstream TCR signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
Regulation of PTEN localization
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood decreased fluid flow , abnormal
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 ZFA:0000008 brain brain hemangiosarcoma increased occurrence , abnormal
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 ZFA:0000088 YSL YSL neutrophil increased amount , abnormal
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 ZFA:0000094 blood island blood island has fewer parts of type neutrophil , abnormal
blood island has extra parts of type macrophage , abnormal
blood island hematopoietic stem cell increased amount , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye hemangiosarcoma increased occurrence , abnormal
eye neoplastic , abnormal
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 ZFA:0000114 heart heart increased size , abnormal
heart edematous , abnormal
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 ZFA:0000117 hypoblast hypoblast cell projection direction , abnormal
hypoblast cell projection physical object quality , abnormal
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 ZFA:0000135 notochord notochord undulate , abnormal
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 ZFA:0000155 somite somite increased width , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein vascular sprouts increased amount , abnormal
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 ZFA:0001058 caudal fin caudal fin falciform , abnormal
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 ZFA:0001078 thymus thymus decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism lethal (sensu genetics) , abnormal
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 ZFA:0001114 head head domed , abnormal
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 ZFA:0001115 trunk trunk neutrophil decreased amount , abnormal
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 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
post-vent region decreased length , abnormal
post-vent region neutrophil decreased amount , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature has extra parts of type blood vessel , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel malformed , abnormal
intersegmental vessel has extra parts of type endothelial cell filopodium, abnormal
intersegmental vessel sprouting angiogenesis increased process quality , abnormal
intersegmental vessel dorsal region increased branchiness , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature has extra parts of type blood vessel , abnormal
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 ZFA:0005898 caudal hematopoietic tissue caudal hematopoietic tissue increased amount , abnormal
caudal hematopoietic tissue erythroblast increased amount , abnormal
caudal hematopoietic tissue hematopoietic stem cell amount , ameliorated
caudal hematopoietic tissue hematopoietic stem cell increased amount , abnormal
caudal hematopoietic tissue neutrophil decreased amount , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell cell proliferation increased occurrence , abnormal
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 ZFA:0009141 macrophage macrophage decreased amount , abnormal
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 ZFA:0009324 myeloid cell myeloid cell increased amount , abnormal
myeloid cell apoptotic process decreased process quality , abnormal
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 ZFA:0009356 myeloid lineage restricted progenitor cell myeloid lineage restricted progenitor cell mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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