ENSGALG00000003634


Gallus gallus

Features
Gene ID: ENSGALG00000003634
  
Biological name :PTEN
  
Synonyms : phosphatase and tensin homolog / PTEN
  
Possible biological names infered from orthology : O08586 / P60484
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 9577947
Gene end: 9621108
  
Corresponding Affymetrix probe sets: Gga.13561.1.S1_s_at (Chicken Array)   Gga.2858.1.S1_at (Chicken Array)   GgaAffx.25913.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005747
NCBI entrez gene - 423675     See in Manteia.
RefSeq - XM_015278701
swissprot - F1NT98
Ensembl - ENSGALG00000003634
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptenaENSDARG00000071018Danio rerio
 ptenbENSDARG00000056623Danio rerio
 PTENENSG00000171862Homo sapiens
 PtenENSMUSG00000013663Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPTE* / TPTE2* / Q6XPS3* / P56180* / transmembrane phosphatase with tensin homology* / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2*ENSGALG0000001703132
TNS3 / tensin 3 / Q5SSZ5* / Q68CZ2*ENSGALG0000003913927
TNS1 / tensin / Q9HBL0* / tensin 1*ENSGALG0000004101326
GAK / cyclin G associated kinase / O14976* / cyclin-G-associated kinase isoform 3 *ENSGALG0000001535221
DNAJC6 / DnaJ heat shock protein family (Hsp40) member C6 / O75061* / Q80TZ3*ENSGALG0000001104121
TNS4 / tensin 4 / Q8BZ33* / Q8IZW8*ENSGALG000000283087


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR014020  Tensin phosphatase, C2 domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR017361  Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation ISA
 biological_processGO:0002902 regulation of B cell apoptotic process ISA
 biological_processGO:0006470 protein dephosphorylation ISA
 biological_processGO:0007270 neuron-neuron synaptic transmission ISA
 biological_processGO:0007416 synapse assembly ISA
 biological_processGO:0007417 central nervous system development ISA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007611 learning or memory ISA
 biological_processGO:0007626 locomotory behavior ISA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010975 regulation of neuron projection development ISA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021542 dentate gyrus development ISA
 biological_processGO:0021955 central nervous system neuron axonogenesis ISA
 biological_processGO:0030336 negative regulation of cell migration ISA
 biological_processGO:0030534 adult behavior ISA
 biological_processGO:0031642 negative regulation of myelination ISA
 biological_processGO:0031647 regulation of protein stability ISA
 biological_processGO:0031658 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle ISA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic ISA
 biological_processGO:0032286 central nervous system myelin maintenance ISA
 biological_processGO:0032535 regulation of cellular component size ISA
 biological_processGO:0033032 regulation of myeloid cell apoptotic process ISA
 biological_processGO:0033555 multicellular organismal response to stress ISA
 biological_processGO:0035176 social behavior ISA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation ISA
 biological_processGO:0036294 cellular response to decreased oxygen levels ISA
 biological_processGO:0042711 maternal behavior ISA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043491 protein kinase B signaling ISA
 biological_processGO:0043542 endothelial cell migration ISA
 biological_processGO:0045475 locomotor rhythm ISA
 biological_processGO:0045792 negative regulation of cell size ISA
 biological_processGO:0046621 negative regulation of organ growth ISA
 biological_processGO:0046855 inositol phosphate dephosphorylation ISA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation ISA
 biological_processGO:0048679 regulation of axon regeneration ISA
 biological_processGO:0048681 negative regulation of axon regeneration ISA
 biological_processGO:0048738 cardiac muscle tissue development ISA
 biological_processGO:0048853 forebrain morphogenesis ISA
 biological_processGO:0048854 brain morphogenesis ISA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050771 negative regulation of axonogenesis ISA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISA
 biological_processGO:0051548 negative regulation of keratinocyte migration IEA
 biological_processGO:0051726 regulation of cell cycle ISA
 biological_processGO:0051895 negative regulation of focal adhesion assembly ISA
 biological_processGO:0051898 negative regulation of protein kinase B signaling ISA
 biological_processGO:0060024 rhythmic synaptic transmission ISA
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation ISA
 biological_processGO:0060070 canonical Wnt signaling pathway ISA
 biological_processGO:0060074 synapse maturation ISA
 biological_processGO:0060134 prepulse inhibition ISA
 biological_processGO:0060179 male mating behavior ISA
 biological_processGO:0060291 long-term synaptic potentiation ISA
 biological_processGO:0060341 regulation of cellular localization ISA
 biological_processGO:0060736 prostate gland growth IEA
 biological_processGO:0060997 dendritic spine morphogenesis ISA
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis ISA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISA
 biological_processGO:0071257 cellular response to electrical stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia ISA
 biological_processGO:0090071 negative regulation of ribosome biogenesis ISA
 biological_processGO:0090344 negative regulation of cell aging ISA
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential ISA
 biological_processGO:0097105 presynaptic membrane assembly ISA
 biological_processGO:0097107 postsynaptic density assembly ISA
 biological_processGO:1903690 negative regulation of wound healing, spreading of epidermal cells IEA
 biological_processGO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway ISA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity ISA
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process ISA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle ISA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential ISA
 biological_processGO:2000808 negative regulation of synaptic vesicle clustering ISA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway ISA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0035749 myelin sheath adaxonal region ISA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure ISA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004438 phosphatidylinositol-3-phosphatase activity ISA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity ISA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity ISA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding ISA
 molecular_functionGO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity ISA
 molecular_functionGO:0016791 phosphatase activity IDA
 molecular_functionGO:0019899 enzyme binding ISA
 molecular_functionGO:0019901 protein kinase binding ISA
 molecular_functionGO:0030165 PDZ domain binding ISA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity ISA
 molecular_functionGO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity ISA
 molecular_functionGO:1990381 ubiquitin-specific protease binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Negative regulation of the PI3K/AKT network
Downstream TCR signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
Regulation of PTEN localization
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr