ENSDARG00000071018


Danio rerio

Features
Gene ID: ENSDARG00000071018
  
Biological name :ptena
  
Synonyms : phosphatase and tensin homolog A / ptena
  
Possible biological names infered from orthology : O08586 / P60484 / phosphatase and tensin homolog / PTEN
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 23650569
Gene end: 23674495
  
Corresponding Affymetrix probe sets: Dr.17113.1.A1_a_at (Zebrafish Array)   Dr.3889.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000109367
Ensembl peptide - ENSDARP00000157011
Ensembl peptide - ENSDARP00000095505
Ensembl peptide - ENSDARP00000095508
Ensembl peptide - ENSDARP00000106446
NCBI entrez gene - 794088     See in Manteia.
RefSeq - NM_200708
RefSeq Peptide - NP_957002
swissprot - F1Q5Y5
swissprot - E7FC59
swissprot - Q6TGR6
swissprot - Q6TGR7
ZFIN ID - ZDB-GENE-030131-3776
Ensembl - ENSDARG00000071018
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTENENSGALG00000003634Gallus gallus
 PTENENSG00000171862Homo sapiens
 PtenENSMUSG00000013663Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptenb / phosphatase and tensin homolog B / PTEN* / O08586* / P60484* / phosphatase and tensin homolog*ENSDARG0000005662379
tpte / transmembrane phosphatase with tensin homology / TPTE2* / Q6XPS3* / P56180* / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2*ENSDARG0000005698526
tns2a / tensin 2a / TNS2* / Q63HR2* / Q8CGB6* / tensin 2* / Mus musculus tensin 2 (Tns2), transcript variant 2, mRNA.*ENSDARG0000007629225
tns1b / tensin 1b / TNS1* / Q9HBL0* / tensin 1*ENSDARG0000002084524
tns1a / tensin 1a / TNS1* / Q9HBL0* / tensin 1*ENSDARG0000007884224
tns2b / tensin 2b / TNS2* / Q63HR2* / Q8CGB6* / tensin 2* / Mus musculus tensin 2 (Tns2), transcript variant 2, mRNA.*ENSDARG0000006839723
gak / cyclin G associated kinase / O14976* / cyclin-G-associated kinase isoform 3 *ENSDARG0000009065419
dnajc6 / DnaJ (Hsp40) homolog, subfamily C, member 6 / O75061* / Q80TZ3* / DnaJ heat shock protein family (Hsp40) member C6*ENSDARG0000007989119
tns3.1 / tensin 3, tandem duplicate 1ENSDARG0000009565415
tns3.2 / tensin 3, tandem duplicate 2 / TNS3* / Q5SSZ5* / Q68CZ2* / tensin 3*ENSDARG000000319118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR014020  Tensin phosphatase, C2 domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR017361  Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0002275 myeloid cell activation involved in immune response IGI
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IGI
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031103 axon regeneration IMP
 biological_processGO:0031174 lifelong otolith mineralization IMP
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0046855 inositol phosphate dephosphorylation IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IMP
 biological_processGO:0051895 negative regulation of focal adhesion assembly IEA
 biological_processGO:0051896 regulation of protein kinase B signaling IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0061515 myeloid cell development IGI
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042577 lipid phosphatase activity IMP
 molecular_functionGO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Negative regulation of the PI3K/AKT network
Downstream TCR signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
Regulation of PTEN localization
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood decreased fluid flow , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000135 notochord notochord undulate , abnormal
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 ZFA:0000217 inner ear inner ear epithelial cell disorganized , abnormal
inner ear epithelial cell aggregated , abnormal
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 ZFA:0001094 whole organism whole organism anterior-posterior axis decreased length , abnormal
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 ZFA:0001114 head head mislocalised ventrally , abnormal
head domed , abnormal
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 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel shape , abnormal
intersegmental vessel malformed , abnormal
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 ZFA:0001617 otolith otolith shape , abnormal
otolith decreased amount , abnormal
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 ZFA:0001717 pillar of the semicircular canal pillar of the semicircular canal unfused from pillar of the semicircular canal , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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