ENSG00000129038


Homo sapiens

Features
Gene ID: ENSG00000129038
  
Biological name :LOXL1
  
Synonyms : LOXL1 / lysyl oxidase like 1 / Q08397
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q24.1
Gene start: 73925989
Gene end: 73952137
  
Corresponding Affymetrix probe sets: 203570_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261921
Ensembl peptide - ENSP00000457827
NCBI entrez gene - 4016     See in Manteia.
OMIM - 153456
RefSeq - XM_017022179
RefSeq - NM_005576
RefSeq Peptide - NP_005567
swissprot - Q08397
swissprot - H3BUV8
Ensembl - ENSG00000129038
  
Related genetic diseases (OMIM): 177650 - {Exfoliation syndrome, susceptibility to}, 177650
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 loxl1ENSDARG00000054451Danio rerio
 Loxl1ENSMUSG00000032334Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LOX / P28300 / lysyl oxidaseENSG0000011308339
LOXL3 / P58215 / lysyl oxidase like 3ENSG0000011531830
LOXL4 / Q96JB6 / lysyl oxidase like 4ENSG0000013813128
LOXL2 / Q9Y4K0 / lysyl oxidase like 2ENSG0000013401327
CD6 / P30203 / CD6 moleculeENSG0000001372510
MARCO / Q9UEW3 / macrophage receptor with collagenous structureENSG000000191696
Q6ZMJ2 / SCARA5 / scavenger receptor class A member 5ENSG000001680795
MSR1 / P21757 / macrophage scavenger receptor 1ENSG000000389455


Protein motifs (from Interpro)
Interpro ID Name
 IPR001695  Lysyl oxidase
 IPR013783  Immunoglobulin-like fold
 IPR019828  Lysyl oxidase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0018277 protein deamination TAS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035904 aorta development IEA
 biological_processGO:0055114 oxidation-reduction process TAS
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000038295 TLL1 / O43897 / tolloid like 1  / reaction
 ENSG00000138829 FBN2 / P35556 / fibrillin 2  / reaction
 ENSG00000166147 FBN1 / P35555 / fibrillin 1  / reaction
 ENSG00000049540 ELN / P15502 / elastin  / reaction
 ENSG00000117122 MFAP2 / P55001 / microfibril associated protein 2  / reaction
 ENSG00000197614 MFAP5 / Q13361 / microfibril associated protein 5  / reaction
 ENSG00000140092 FBLN5 / Q9UBX5 / fibulin 5  / reaction
 ENSG00000168487 BMP1 / P13497 / bone morphogenetic protein 1  / reaction






 

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