ENSG00000038945


Homo sapiens

Features
Gene ID: ENSG00000038945
  
Biological name :MSR1
  
Synonyms : macrophage scavenger receptor 1 / MSR1 / P21757
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p22
Gene start: 16107878
Gene end: 16567490
  
Corresponding Affymetrix probe sets: 208422_at (Human Genome U133 Plus 2.0 Array)   208423_s_at (Human Genome U133 Plus 2.0 Array)   211887_x_at (Human Genome U133 Plus 2.0 Array)   214770_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000371428
Ensembl peptide - ENSP00000405453
Ensembl peptide - ENSP00000430536
Ensembl peptide - ENSP00000429498
Ensembl peptide - ENSP00000428865
Ensembl peptide - ENSP00000427905
Ensembl peptide - ENSP00000262100
Ensembl peptide - ENSP00000262101
Ensembl peptide - ENSP00000347430
NCBI entrez gene - 4481     See in Manteia.
OMIM - 153622
RefSeq - NM_138715
RefSeq - NM_138716
RefSeq - NM_002445
RefSeq Peptide - NP_002436
RefSeq Peptide - NP_619729
RefSeq Peptide - NP_619730
swissprot - P21757
swissprot - E5RFW8
swissprot - E5RFI4
swissprot - B4DDJ5
swissprot - H0YBY2
swissprot - E5RI91
Ensembl - ENSG00000038945
  
Related genetic diseases (OMIM): 614266 - Barrett esophagus/esophageal adenocarcinoma, 614266
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Msr1ENSMUSG00000025044Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZMJ2 / SCARA5 / scavenger receptor class A member 5ENSG0000016807936
MARCO / Q9UEW3 / macrophage receptor with collagenous structureENSG0000001916926
LOXL2 / Q9Y4K0 / lysyl oxidase like 2ENSG0000013401318
LOXL4 / Q96JB6 / lysyl oxidase like 4ENSG0000013813117
LOXL3 / P58215 / lysyl oxidase like 3ENSG0000011531817
CD6 / P30203 / CD6 moleculeENSG0000001372514
LOXL1 / Q08397 / lysyl oxidase like 1ENSG000001290386
LOX / P28300 / lysyl oxidaseENSG000001130834


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR003543  Macrophage scavenger receptor
 IPR008160  Collagen triple helix repeat
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR017448  SRCR-like domain
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis NAS
 biological_processGO:0006911 phagocytosis, engulfment ISS
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation ISS
 biological_processGO:0010886 positive regulation of cholesterol storage ISS
 biological_processGO:0030301 cholesterol transport ISS
 biological_processGO:0034381 plasma lipoprotein particle clearance ISS
 biological_processGO:0042953 lipoprotein transport IEA
 biological_processGO:0097242 amyloid-beta clearance ISS
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0034362 low-density lipoprotein particle IEA
 molecular_functionGO:0001540 amyloid-beta binding ISS
 molecular_functionGO:0005044 scavenger receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030169 low-density lipoprotein particle binding ISS


Pathways (from Reactome)
Pathway description
Scavenging by Class A Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
Show

 HP:0001428 Somatic mutation 
Show

 HP:0011459 Esophageal carcinoma "The presence of a `carcinoma` (MPATH:549) of the `esophagus` (FMA:7131)." [DDD:hfirth]
Show

 HP:0012125 Prostate cancer "A cancer of the `prostate` (FMA:9600)." [HPO:probinson]
Show

 HP:0100580 Barrett esophagus "An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system." [HPO:sdoelken]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000038945 MSR1 / P21757 / macrophage scavenger receptor 1  / complex
 ENSG00000134871 COL4A2 / P08572 / collagen type IV alpha 2 chain  / complex / reaction
 ENSG00000187498 COL4A1 / P02462 / collagen type IV alpha 1 chain  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr