ENSG00000019169


Homo sapiens

Features
Gene ID: ENSG00000019169
  
Biological name :MARCO
  
Synonyms : macrophage receptor with collagenous structure / MARCO / Q9UEW3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q14.2
Gene start: 118942166
Gene end: 118994660
  
Corresponding Affymetrix probe sets: 205819_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409192
Ensembl peptide - ENSP00000318916
NCBI entrez gene - 8685     See in Manteia.
OMIM - 604870
RefSeq - XM_011512083
RefSeq - NM_006770
RefSeq - XM_011512082
RefSeq Peptide - NP_006761
swissprot - Q4ZG40
swissprot - Q9UEW3
swissprot - C9JKT8
Ensembl - ENSG00000019169
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 marcoENSDARG00000059294Danio rerio
 MARCOENSGALG00000012119Gallus gallus
 MarcoENSMUSG00000026390Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MSR1 / P21757 / macrophage scavenger receptor 1ENSG0000003894523
Q6ZMJ2 / SCARA5 / scavenger receptor class A member 5ENSG0000016807923
LOXL2 / Q9Y4K0 / lysyl oxidase like 2ENSG0000013401315
LOXL4 / Q96JB6 / lysyl oxidase like 4ENSG0000013813114
LOXL3 / P58215 / lysyl oxidase like 3ENSG0000011531814
CD6 / P30203 / CD6 moleculeENSG0000001372512
LOXL1 / Q08397 / lysyl oxidase like 1ENSG000001290387
LOX / P28300 / lysyl oxidaseENSG000001130834


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR008160  Collagen triple helix repeat
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR017448  SRCR-like domain
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0002221 pattern recognition receptor signaling pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0097242 amyloid-beta clearance ISS
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005622 intracellular ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 molecular_functionGO:0001540 amyloid-beta binding ISS
 molecular_functionGO:0001664 G-protein coupled receptor binding ISS
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0008329 signaling pattern recognition receptor activity TAS


Pathways (from Reactome)
Pathway description
Scavenging by Class A Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019169 MARCO / Q9UEW3 / macrophage receptor with collagenous structure  / complex






 

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