ENSG00000134013


Homo sapiens

Features
Gene ID: ENSG00000134013
  
Biological name :LOXL2
  
Synonyms : LOXL2 / lysyl oxidase like 2 / Q9Y4K0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p21.3
Gene start: 23297189
Gene end: 23425328
  
Corresponding Affymetrix probe sets: 202997_s_at (Human Genome U133 Plus 2.0 Array)   202998_s_at (Human Genome U133 Plus 2.0 Array)   202999_s_at (Human Genome U133 Plus 2.0 Array)   228808_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427883
Ensembl peptide - ENSP00000473322
Ensembl peptide - ENSP00000430519
Ensembl peptide - ENSP00000429778
Ensembl peptide - ENSP00000428933
Ensembl peptide - ENSP00000428497
Ensembl peptide - ENSP00000427907
Ensembl peptide - ENSP00000373783
Ensembl peptide - ENSP00000427826
NCBI entrez gene - 4017     See in Manteia.
OMIM - 606663
RefSeq - NM_002318
RefSeq Peptide - NP_002309
swissprot - E5RFY0
swissprot - E5RFE2
swissprot - H0YAP6
swissprot - H0YAR1
swissprot - Q9Y4K0
swissprot - E5RJL2
swissprot - R4GMS2
swissprot - E5RI22
swissprot - E5RHH3
Ensembl - ENSG00000134013
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A1L1V4ENSDARG00000044074Danio rerio
 F1QQC3ENSDARG00000044010Danio rerio
 ENSGALG00000038458Gallus gallus
 Loxl2ENSMUSG00000034205Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LOXL3 / P58215 / lysyl oxidase like 3ENSG0000011531854
LOXL4 / Q96JB6 / lysyl oxidase like 4ENSG0000013813153
LOXL1 / Q08397 / lysyl oxidase like 1ENSG0000012903820
CD6 / P30203 / CD6 moleculeENSG0000001372518
LOX / P28300 / lysyl oxidaseENSG0000011308317
Q6ZMJ2 / SCARA5 / scavenger receptor class A member 5ENSG0000016807910
MARCO / Q9UEW3 / macrophage receptor with collagenous structureENSG0000001916910
MSR1 / P21757 / macrophage scavenger receptor 1ENSG0000003894510


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001695  Lysyl oxidase
 IPR017448  SRCR-like domain
 IPR019828  Lysyl oxidase, conserved site
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IDA
 biological_processGO:0001935 endothelial cell proliferation IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006464 cellular protein modification process IDA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007568 aging TAS
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0018057 peptidyl-lysine oxidation IDA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0046688 response to copper ion IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070828 heterochromatin organization IMP
 biological_processGO:1902455 negative regulation of stem cell population maintenance IEA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane ISS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031012 extracellular matrix HDA
 molecular_functionGO:0004720 protein-lysine 6-oxidase activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070492 oligosaccharide binding IDA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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