ENSMUSG00000030224


Mus musculus

Features
Gene ID: ENSMUSG00000030224
  
Biological name :Strap
  
Synonyms : Q9Z1Z2 / serine/threonine kinase receptor associated protein / Strap
  
Possible biological names infered from orthology : Q9Y3F4
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G1
Gene start: 137735078
Gene end: 137751932
  
Corresponding Affymetrix probe sets: 10542445 (MoGene1.0st)   1416566_at (Mouse Genome 430 2.0 Array)   1419912_s_at (Mouse Genome 430 2.0 Array)   1419913_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068267
NCBI entrez gene - 20901     See in Manteia.
MGI - MGI:1329037
RefSeq - NM_011499
RefSeq Peptide - NP_035629
swissprot - B2RUC7
swissprot - Q9Z1Z2
Ensembl - ENSMUSG00000030224
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 strapENSDARG00000007405Danio rerio
 STRAPENSGALG00000013092Gallus gallus
 STRAPENSG00000023734Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif3i / Q9QZD9 / Eukaryotic translation initiation factor 3 subunit I / Q13347*ENSMUSG0000002879823


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000387 spliceosomal snRNP assembly ISO
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration ISO
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030277 maintenance of gastrointestinal epithelium ISO
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032797 SMN complex ISO
 cellular_componentGO:0034719 SMN-Sm protein complex ISO
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of TGF-beta receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tnftm1.1Sned/Tnftm1.1Sned,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032440 Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*  / complex
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / reaction / complex
 ENSMUSG00000002603 Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*  / complex
 ENSMUSG00000007613 Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*  / complex






 

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