ENSG00000023734


Homo sapiens

Features
Gene ID: ENSG00000023734
  
Biological name :STRAP
  
Synonyms : Q9Y3F4 / serine/threonine kinase receptor associated protein / STRAP
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p12.3
Gene start: 15882391
Gene end: 15903478
  
Corresponding Affymetrix probe sets: 1558002_at (Human Genome U133 Plus 2.0 Array)   200870_at (Human Genome U133 Plus 2.0 Array)   236916_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000025399
Ensembl peptide - ENSP00000392270
Ensembl peptide - ENSP00000445693
Ensembl peptide - ENSP00000445814
NCBI entrez gene - 11171     See in Manteia.
OMIM - 605986
RefSeq - XM_005253294
RefSeq - NM_007178
RefSeq Peptide - NP_009109
swissprot - F5H1G1
swissprot - Q9Y3F4
swissprot - H0YH33
Ensembl - ENSG00000023734
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 strapENSDARG00000007405Danio rerio
 STRAPENSGALG00000013092Gallus gallus
 StrapENSMUSG00000030224Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF3I / Q13347 / eukaryotic translation initiation factor 3 subunit IENSG0000008462323


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000387 spliceosomal snRNP assembly IDA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration IMP
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0030277 maintenance of gastrointestinal epithelium IMP
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032797 SMN complex IDA
 cellular_componentGO:0034719 SMN-Sm protein complex IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of TGF-beta receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / complex / reaction
 ENSG00000163513 P37173 / TGFBR2 / transforming growth factor beta receptor 2  / complex / reaction
 ENSG00000106799 P36897 / TGFBR1 / transforming growth factor beta receptor 1  / reaction / complex
 ENSG00000101665 SMAD7 / O15105 / SMAD family member 7  / reaction / complex






 

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