21803


Mus musculus (NCBI)

Features
Gene ID: 21803
  
Biological name :
  
Synonyms : Tgfb1 / TGF-beta1|TGFbeta1|Tgfb|Tgfb-1 / transforming growth factor, beta 1
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1420653_at (Mouse Genome 430 2.0 Array)   1445360_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 6755775
RefSeq - NC_000073.6
RefSeq - NP_035707.1
RefSeq - NM_011577.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000002603 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation ISO
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0000165 MAPK cascade ISO
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001657 ureteric bud development IEP
 biological_processGO:0001763 morphogenesis of a branching structure ISO
 biological_processGO:0001775 cell activation IDA
 biological_processGO:0001837 epithelial to mesenchymal transition ISO
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation ISO
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0002028 regulation of sodium ion transport IDA
 biological_processGO:0002062 chondrocyte differentiation ISO
 biological_processGO:0002244 hematopoietic progenitor cell differentiation ISO
 biological_processGO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment TAS
 biological_processGO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains IDA
 biological_processGO:0002513 tolerance induction to self antigen IMP
 biological_processGO:0003179 heart valve morphogenesis IMP
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006611 protein export from nucleus ISO
 biological_processGO:0006754 ATP biosynthetic process ISO
 biological_processGO:0006796 phosphate-containing compound metabolic process ISO
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006952 defense response TAS
 biological_processGO:0006954 inflammatory response ISO
 biological_processGO:0007050 cell cycle arrest ISO
 biological_processGO:0007093 mitotic cell cycle checkpoint ISO
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway ISO
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0007182 common-partner SMAD protein phosphorylation ISO
 biological_processGO:0007183 SMAD protein complex assembly ISO
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007406 negative regulation of neuroblast proliferation ISO
 biological_processGO:0007492 endoderm development IDA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007519 skeletal muscle tissue development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0008354 germ cell migration IDA
 biological_processGO:0009817 defense response to fungus, incompatible interaction ISO
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010033 response to organic substance ISO
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISO
 biological_processGO:0010763 positive regulation of fibroblast migration ISO
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation ISO
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0010936 negative regulation of macrophage cytokine production ISO
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0016202 regulation of striated muscle tissue development IDA
 biological_processGO:0016477 cell migration ISO
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0019049 evasion or tolerance of host defenses by virus ISO
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0022408 negative regulation of cell-cell adhesion ISO
 biological_processGO:0030214 hyaluronan catabolic process ISO
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0030279 negative regulation of ossification IDA
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0030316 osteoclast differentiation IGI
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0030879 mammary gland development IDA
 biological_processGO:0031065 positive regulation of histone deacetylation IDA
 biological_processGO:0031100 animal organ regeneration ISO
 biological_processGO:0031293 membrane protein intracellular domain proteolysis ISO
 biological_processGO:0031334 positive regulation of protein complex assembly ISO
 biological_processGO:0031536 positive regulation of exit from mitosis ISO
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway ISO
 biological_processGO:0032270 positive regulation of cellular protein metabolic process ISO
 biological_processGO:0032355 response to estradiol ISO
 biological_processGO:0032570 response to progesterone ISO
 biological_processGO:0032667 regulation of interleukin-23 production IDA
 biological_processGO:0032700 negative regulation of interleukin-17 production IDA
 biological_processGO:0032740 positive regulation of interleukin-17 production ISO
 biological_processGO:0032801 receptor catabolic process ISO
 biological_processGO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation TAS
 biological_processGO:0032930 positive regulation of superoxide anion generation ISO
 biological_processGO:0032943 mononuclear cell proliferation IMP
 biological_processGO:0032967 positive regulation of collagen biosynthetic process ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0035066 positive regulation of histone acetylation IDA
 biological_processGO:0035307 positive regulation of protein dephosphorylation ISO
 biological_processGO:0042060 wound healing ISO
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0042306 regulation of protein import into nucleus IDA
 biological_processGO:0042307 positive regulation of protein import into nucleus ISO
 biological_processGO:0042482 positive regulation of odontogenesis IDA
 biological_processGO:0042552 myelination ISO
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043011 myeloid dendritic cell differentiation IMP
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043117 positive regulation of vascular permeability ISO
 biological_processGO:0043406 positive regulation of MAP kinase activity ISO
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0043491 protein kinase B signaling ISO
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration ISO
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration ISO
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISO
 biological_processGO:0045066 regulatory T cell differentiation IMP
 biological_processGO:0045216 cell-cell junction organization ISO
 biological_processGO:0045589 regulation of regulatory T cell differentiation IGI
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IMP
 biological_processGO:0045599 negative regulation of fat cell differentiation ISO
 biological_processGO:0045662 negative regulation of myoblast differentiation ISO
 biological_processGO:0045786 negative regulation of cell cycle ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045930 negative regulation of mitotic cell cycle ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048146 positive regulation of fibroblast proliferation IDA
 biological_processGO:0048298 positive regulation of isotype switching to IgA isotypes ISO
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048535 lymph node development IMP
 biological_processGO:0048642 negative regulation of skeletal muscle tissue development ISO
 biological_processGO:0050679 positive regulation of epithelial cell proliferation ISO
 biological_processGO:0050680 negative regulation of epithelial cell proliferation ISO
 biological_processGO:0050714 positive regulation of protein secretion ISO
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050765 negative regulation of phagocytosis ISO
 biological_processGO:0050777 negative regulation of immune response ISO
 biological_processGO:0050868 negative regulation of T cell activation IMP
 biological_processGO:0050921 positive regulation of chemotaxis ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051098 regulation of binding IDA
 biological_processGO:0051101 regulation of DNA binding IDA
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation ISO
 biological_processGO:0051280 negative regulation of release of sequestered calcium ion into cytosol ISO
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060325 face morphogenesis IEP
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0060390 regulation of SMAD protein signal transduction ISO
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction ISO
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0060744 mammary gland branching involved in thelarche IMP
 biological_processGO:0060751 branch elongation involved in mammary gland duct branching IMP
 biological_processGO:0060762 regulation of branching involved in mammary gland duct morphogenesis IGI
 biological_processGO:0060965 negative regulation of gene silencing by miRNA ISO
 biological_processGO:0061035 regulation of cartilage development IDA
 biological_processGO:0070168 negative regulation of biomineral tissue development ISO
 biological_processGO:0070306 lens fiber cell differentiation IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0070723 response to cholesterol ISO
 biological_processGO:0071158 positive regulation of cell cycle arrest IDA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071407 cellular response to organic cyclic compound ISO
 biological_processGO:0071549 cellular response to dexamethasone stimulus ISO
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus ISO
 biological_processGO:0071677 positive regulation of mononuclear cell migration ISO
 biological_processGO:0072540 T-helper 17 cell lineage commitment TAS
 biological_processGO:0085029 extracellular matrix assembly ISO
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis ISO
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 biological_processGO:1900126 negative regulation of hyaluronan biosynthetic process ISO
 biological_processGO:1900182 positive regulation of protein localization to nucleus ISO
 biological_processGO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity ISO
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II ISO
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane ISO
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA ISO
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
 biological_processGO:1903911 positive regulation of receptor clustering IDA
 biological_processGO:1905005 regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
 biological_processGO:1905313 transforming growth factor beta receptor signaling pathway involved in heart development IMP
 biological_processGO:1990402 embryonic liver development IMP
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IGI
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding ISO
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005902 microvillus ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0030141 secretory granule ISO
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0043025 neuronal cell body ISO
 molecular_functionGO:0003823 antigen binding ISO
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding ISO
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding ISO
 molecular_functionGO:0034714 type III transforming growth factor beta receptor binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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