ENSMUSG00000024232


Mus musculus

Features
Gene ID: ENSMUSG00000024232
  
Biological name :Bambi
  
Synonyms : Bambi / BMP and activin membrane-bound inhibitor homolog / Q9D0L6
  
Possible biological names infered from orthology : BMP and activin membrane bound inhibitor / Q13145
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A1
Gene start: 3507957
Gene end: 3516404
  
Corresponding Affymetrix probe sets: 10453604 (MoGene1.0st)   1423753_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025075
NCBI entrez gene - 68010     See in Manteia.
MGI - MGI:1915260
RefSeq - NM_026505
RefSeq Peptide - NP_080781
swissprot - Q9D0L6
Ensembl - ENSMUSG00000024232
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bambiaENSDARG00000055381Danio rerio
 bambibENSDARG00000099677Danio rerio
 BAMBIENSGALG00000040993Gallus gallus
 BAMBIENSG00000095739Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009345  BMP and activin membrane-bound inhibitor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005109 frizzled binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of TGF-beta receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Rhotm1Jlem/Rho+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Rhotm1Jlem/Rho+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Bambitm1Mahu/Bambi+
Genetic Background: B6.Cg-Bambitm1Mahu

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Comptm1Mbri/Comp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Rhotm1Jlem/Rho+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Bambitm1Mahu/Bambi+
Genetic Background: B6.Cg-Bambitm1Mahu

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Rhotm1Jlem/Rho+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002603 Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*  / complex / reaction
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / complex / reaction
 ENSMUSG00000032440 Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*  / reaction / complex
 ENSMUSG00000007613 Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*  / reaction / complex






 

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