ENSMUSG00000026100


Mus musculus

Features
Gene ID: ENSMUSG00000026100
  
Biological name :Mstn
  
Synonyms : Mstn / myostatin / O08689
  
Possible biological names infered from orthology : O14793
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.1
Gene start: 53061640
Gene end: 53068079
  
Corresponding Affymetrix probe sets: 10346250 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000140249
Ensembl peptide - ENSMUSP00000027269
NCBI entrez gene - 17700     See in Manteia.
MGI - MGI:95691
RefSeq - NM_010834
RefSeq Peptide - NP_034964
swissprot - A0A087WQL8
swissprot - O08689
swissprot - Q540E2
Ensembl - ENSMUSG00000026100
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mstnaENSDARG00000042947Danio rerio
 mstnbENSDARG00000069133Danio rerio
 GDF8ENSGALG00000039458Gallus gallus
 MSTNENSG00000138379Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535262
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125327
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923927
Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*ENSMUSG0000000260326
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132422
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703521
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011720
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749220
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540519
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717117
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327917
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194316
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740815
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952315
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823814
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933511
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850811


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR015616  Growth/differentiation factor 8
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009629 response to gravity IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0014732 skeletal muscle atrophy IEA
 biological_processGO:0014741 negative regulation of muscle hypertrophy IEA
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0022602 ovulation cycle process IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0033673 negative regulation of kinase activity IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043403 skeletal muscle tissue regeneration IEA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 biological_processGO:0046716 muscle cell cellular homeostasis IEA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048632 negative regulation of skeletal muscle tissue growth IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IDA
 biological_processGO:1902723 negative regulation of skeletal muscle satellite cell proliferation ISS
 biological_processGO:1902725 negative regulation of satellite cell differentiation ISS
 biological_processGO:2000818 negative regulation of myoblast proliferation ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Cul3tm1Jro/Cul3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000440 domed skull 
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cul3tm1Jro/Cul3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mstntm1.1Mgs/Mstntm1.1Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * FVB/N

Allelic Composition: Mstntm3.1Sjl/Mstntm3.1Sjl,Tg(CDX2-cre)101Erf/0
Genetic Background: B6.Cg-Mstntm3.1Sjl Tg(CDX2-cre)101Erf/Sjl

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Dsg4lah/Dsg4lah
Genetic Background: LAH/Pas

Allelic Composition: Mstntm1.1Swel/Mstntm1.1Swel
Genetic Background: involves: 129S7/SvEvBrd-Hprt1 * C57BL/6J * FVB/N

Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mstntm1.1Mgs/Mstntm1.1Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * FVB/N

Allelic Composition: MstnCmpt/Mstn+
Genetic Background: either: HCI or HCR

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fmr1tm1Usdn/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB

Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

Allelic Composition: Fsttm1Zuk/Fst+,Mstntm1Sjl/Mstn+
Genetic Background: B6.129-Mstntm1Sjl Fsttm1Zuk

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn,Ightm1Mnz/Ightm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Numa1tm1.2Dwc/Numa1tm1.2Dwc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn,Ightm1Mnz/Ightm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fmr1tm1Usdn/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB

Allelic Composition: Mstntm1.1Mgs/Mstntm1.1Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * FVB/N

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dsg4lah/Dsg4lah
Genetic Background: LAH/Pas

Allelic Composition: MstnCmpt/Mstn+
Genetic Background: either: HCI or HCR

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1ctm2Itl/Cacna1c+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cul3tm1Jro/Cul3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0003397 increased muscle weight "greater than average muscle weight" [J:94134, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dsg4lah/Dsg4lah
Genetic Background: LAH/Pas

Allelic Composition: Mstntm1.1Swel/Mstntm1.1Swel
Genetic Background: involves: 129S7/SvEvBrd-Hprt1 * C57BL/6J * FVB/N

Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003398 increased skeletal muscle size "greater than average dimensions of one or more of the muscles of the skeleton" [J:94134, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mstntm1.1Mgs/Mstntm1.1Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * FVB/N

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mstntm2Sjl/Mstn+
Genetic Background: B6.129-Mstntm2Sjl

Allelic Composition: Mstntm3.1Sjl/Mstntm3.1Sjl,Tg(CDX2-cre)101Erf/0
Genetic Background: B6.Cg-Mstntm3.1Sjl Tg(CDX2-cre)101Erf/Sjl

Allelic Composition: Mstntm1Sjl/Mstn+
Genetic Background: B6N.129-Mstntm1Sjl

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cul3tm1Jro/Cul3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004508 abnormal shoulder bone morphology "any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004627 abnormal trochanter morphology "any structural anomaly of the bony prominences near the upper extremity of the femur; there are two in human (greater and lesser trochanters) and three in many other mammalian species (greater, lesser and third); these normally serve as attachment points for hip and thigh muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cul3tm1Jro/Cul3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004645 decreased vertebrae number "a reduction from the normal number of the bony segments of the spinal column" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004650 increased lumbar vertebrae number "increased number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Gdf11tm2.2Sjl/Gdf11tm2.2Sjl
Genetic Background: involves: C57BL/6 * CBA * FVB

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstn+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004656 absent sacral vertebrae "absence of all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004818 increased skeletal muscle mass "increase in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo1tm1.1Ssp/Pygo1+,Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mstntm2Sjl/Mstntm2Sjl
Genetic Background: B6.129-Mstntm2Sjl

Allelic Composition: Mstntm2Sjl/Mstn+
Genetic Background: B6.129-Mstntm2Sjl

Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: B6N.129-Mstntm1Sjl

Allelic Composition: MstnCmpt/Mstn+
Genetic Background: either: HCI or HCR

Allelic Composition: MstnCmpt/MstnCmpt
Genetic Background: BEH

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mstntm1.1Mgs/Mstntm1.1Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * FVB/N

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0005451 abnormal body composition "anomalous relative amounts of various components of the body, such as percent body fat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: MstnCmpt/Mstn+
Genetic Background: either: HCI or HCR

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0008552 abnormal circulating tumor necrosis factor level "anomaly in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009301 decreased parametrial fat pad weight 
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dsg4lah/Dsg4lah
Genetic Background: LAH/Pas

Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo1tm1.1Ssp/Pygo1+,Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mstntm2Sjl/Mstntm2Sjl
Genetic Background: B6.129-Mstntm2Sjl

Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: B6N.129-Mstntm1Sjl

 MP:0009405 increased skeletal muscle fiber number "increased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mstntm2Sjl/Mstntm2Sjl
Genetic Background: B6.129-Mstntm2Sjl

Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: B6N.129-Mstntm1Sjl

 MP:0009421 increased gastrocnemius weight "increase in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0009459 skeletal muscle hyperplasia "overdevelopment or increased size of the skeletal muscle, usually due an increased number of cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mstntm3.1Sjl/Mstntm3.1Sjl,Tg(CDX2-cre)101Erf/0
Genetic Background: B6.Cg-Mstntm3.1Sjl Tg(CDX2-cre)101Erf/Sjl

 MP:0009461 skeletal muscle hypertrophy "increase in the bulk size of the skeletal muscle due to cell enlargement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dsg4lah/Dsg4lah
Genetic Background: LAH/Pas

Allelic Composition: Mstntm1.1Mgs/Mstntm1.1Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * FVB/N

Allelic Composition: Mstntm3.1Sjl/Mstntm3.1Sjl,Tg(CDX2-cre)101Erf/0
Genetic Background: B6.Cg-Mstntm3.1Sjl Tg(CDX2-cre)101Erf/Sjl

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cul3tm1Jro/Cul3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010226 increased quadriceps weight "increase in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cul3tm1Jro/Cul3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Mstnlean/Mstnlean
Genetic Background: C57BL/6J-Mstnlean

 MP:0010238 increased skeletal muscle weight "greater than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mstntm1.1Mgs/Mstntm1.1Mgs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * FVB/N

Allelic Composition: Mstntm3.1Sjl/Mstntm3.1Sjl,Tg(CDX2-cre)101Erf/0
Genetic Background: B6.Cg-Mstntm3.1Sjl Tg(CDX2-cre)101Erf/Sjl

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fsttm1Zuk/Fst+,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: B6.129-Mstntm1Sjl Fsttm1Zuk

Allelic Composition: Fsttm1Zuk/Fst+,Mstntm1Sjl/Mstn+
Genetic Background: B6.129-Mstntm1Sjl Fsttm1Zuk

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gdf11tm1Sjl/Gdf11tm1Sjl,Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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