ENSDARG00000069133


Danio rerio

Features
Gene ID: ENSDARG00000069133
  
Biological name :mstnb
  
Synonyms : mstnb / myostatin b / O42222
  
Possible biological names infered from orthology : MSTN / myostatin / O08689 / O14793
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 40939336
Gene end: 40943137
  
Corresponding Affymetrix probe sets: Dr.5778.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000091159
NCBI entrez gene - 798441     See in Manteia.
RefSeq - NM_131019
RefSeq Peptide - NP_571094
swissprot - O42222
ZFIN ID - ZDB-GENE-990415-165
Ensembl - ENSDARG00000069133
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GDF8ENSGALG00000039458Gallus gallus
 MSTNENSG00000138379Homo sapiens
 MstnENSMUSG00000026100Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mstna / myostatin a / MSTN* / O14793* / O08689* / myostatin*ENSDARG0000004294766
gdf11 / growth differentiation factor 11 / O95390* / Q9Z1W4*ENSDARG0000004492463
tgfb3 / transforming growth factor, beta 3 / P10600*ENSDARG0000001936726
tgfb2 / transforming growth factor, beta 2 / P27090* / P61812* / Transforming growth factor beta-2 Latency-associated peptide*ENSDARG0000002708725
tgfb2l / transforming growth factor, beta 2, likeENSDARG0000007187925
tgfb1a / transforming growth factor, beta 1a / TGFB1* / P01137* / transforming growth factor beta 1*ENSDARG0000004150224
tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*ENSDARG0000003489522
inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*ENSDARG0000004077722
inhbab / inhibin, beta Ab / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000002475921
inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000001267121
gdf3 / P35621 / growth differentiation factor 3 / GDF1* / CERS1* / Q9NR23* / P27544* / P27545* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 1* / Embr...ENSDARG0000003799520
INHBE / inhibin beta E subunit / INHBC* / P58166* / P55103* / inhibin beta C subunit*ENSDARG0000010098620
CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*ENSDARG0000010389217
gdf10b / growth differentiation factor 10b / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000007389116
bmp3 / bone morphogenetic protein 3 / P12645* / Q8BHE5* / Bone morphotic protein 3 *ENSDARG0000006052616
ndr1 / nodal-related 1 / NODAL* / Q96S42* / P43021* / nodal growth differentiation factor*ENSDARG0000005709616
gdf10a / growth differentiation factor 10a / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000009537816
ndr2 / nodal-related 2 / NODAL* / Q96S42* / nodal growth differentiation factor*ENSDARG0000010127915
spaw / southpaw / NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*ENSDARG0000001430914
gdf9 / growth differentiation factor 9 / O60383* / Q07105*ENSDARG0000000322913


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway NAS
 biological_processGO:0007517 muscle organ development IDA
 biological_processGO:0007519 skeletal muscle tissue development IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045843 negative regulation of striated muscle tissue development IDA
 biological_processGO:0045926 negative regulation of growth IDA
 biological_processGO:0045967 negative regulation of growth rate IDA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood glucose increased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism increased weight , abnormal
Show

 ZFA:0005145 muscle muscle increased amount , abnormal
muscle hyperplastic , abnormal
muscle decreased amount , abnormal
Show

 ZFA:0005277 skeletal muscle skeletal muscle triglyceride increased amount , abnormal
skeletal muscle lipid increased amount , abnormal
Show

 ZFA:0005345 adipose tissue adipose tissue decreased amount , abnormal
Show

 ZFA:0009114 muscle cell muscle cell hyperplastic , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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