ENSDARG00000037995


Danio rerio

Features
Gene ID: ENSDARG00000037995
  
Biological name :gdf3
  
Synonyms : gdf3 / growth differentiation factor 3 / P35621
  
Possible biological names infered from orthology : ceramide synthase 1 / CERS1 / Embryonic growth/differentiation factor 1 / GDF1 / growth differentiation factor 1 / P20863 / P27539 / P27544 / P27545 / Q07104 / Q9NR23
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 4239437
Gene end: 4252221
  
Corresponding Affymetrix probe sets: Dr.307.1.S1_at (Zebrafish Array)   NM_130948_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000126365
Ensembl peptide - ENSDARP00000126546
Ensembl peptide - ENSDARP00000055378
NCBI entrez gene - 30125     See in Manteia.
RefSeq - NM_130948
RefSeq Peptide - NP_571023
swissprot - K7DYL7
swissprot - K7DY39
swissprot - P35621
ZFIN ID - ZDB-GENE-980526-389
Ensembl - ENSDARG00000037995
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GDF3ENSGALG00000003161Gallus gallus
 CERS1ENSG00000223802Homo sapiens
 GDF1ENSG00000130283Homo sapiens
 GDF3ENSG00000184344Homo sapiens
 Cers1ENSMUSG00000087408Mus musculus
 Gdf1ENSMUSG00000109523Mus musculus
 Gdf3ENSMUSG00000030117Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tgfb3 / transforming growth factor, beta 3 / P10600*ENSDARG0000001936722
gdf10a / growth differentiation factor 10a / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000009537822
spaw / southpaw / NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*ENSDARG0000001430922
ndr1 / nodal-related 1 / NODAL* / Q96S42* / P43021* / nodal growth differentiation factor*ENSDARG0000005709621
ndr2 / nodal-related 2 / NODAL* / Q96S42* / nodal growth differentiation factor*ENSDARG0000010127921
mstnb / O42222 / myostatin b / MSTN* / O08689* / O14793* / myostatin*ENSDARG0000006913321
tgfb2 / transforming growth factor, beta 2 / P27090* / P61812* / Transforming growth factor beta-2 Latency-associated peptide*ENSDARG0000002708720
tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*ENSDARG0000003489520
bmp3 / bone morphogenetic protein 3 / P12645* / Q8BHE5* / Bone morphotic protein 3 *ENSDARG0000006052620
mstna / myostatin a / MSTN* / O14793* / O08689* / myostatin*ENSDARG0000004294720
gdf11 / growth differentiation factor 11 / O95390* / Q9Z1W4*ENSDARG0000004492420
gdf10b / growth differentiation factor 10b / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000007389120
INHBE / inhibin beta E subunit / INHBC* / P58166* / P55103* / inhibin beta C subunit*ENSDARG0000010098619
tgfb2l / transforming growth factor, beta 2, likeENSDARG0000007187919
tgfb1a / transforming growth factor, beta 1a / TGFB1* / P01137* / transforming growth factor beta 1*ENSDARG0000004150219
inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000001267119
inhbab / inhibin, beta Ab / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000002475919
inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*ENSDARG0000004077718
bmp15 / bone morphogenetic protein 15ENSDARG0000003749117
CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*ENSDARG0000010389216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:1900145 regulation of nodal signaling pathway involved in determination of left/right asymmetry IMP
 biological_processGO:1904086 regulation of epiboly involved in gastrulation with mouth forming second IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle motile cilium decreased length , abnormal
Show

 ZFA:0000008 brain brain neuron decreased branchiness , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
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 ZFA:0000035 lens lens decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate mislocalised posteriorly , abnormal
Show

 ZFA:0000101 diencephalon diencephalon bilateral symmetry , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye perforate , abnormal
Show

 ZFA:0000114 heart heart bilateral symmetry , abnormal
heart tubular , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm determination of left/right asymmetry in lateral mesoderm decreased process quality , abnormal
Show

 ZFA:0000132 neural plate neural plate increased width , abnormal
Show

 ZFA:0000135 notochord notochord decreased length , abnormal
notochord length , ameliorated
notochord width , ameliorated
notochord shape , ameliorated
notochord curved , abnormal
Show

 ZFA:0000152 retina retina decreased size , abnormal
retina photoreceptor outer segment absent , abnormal
retina photoreceptor outer segment decreased length , abnormal
Show

 ZFA:0000155 somite somite distended , abnormal
somite antero-posteriorly flattened , abnormal
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 ZFA:0000360 heart tube heart tube bilateral symmetry , abnormal
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 ZFA:0000434 skeletal system skeletal system morphology , abnormal
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 ZFA:0001064 rhombomere rhombomere increased width , abnormal
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 ZFA:0001115 trunk trunk curved , abnormal
trunk neuron development disrupted , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region curved ventral , abnormal
post-vent region neuron development disrupted , abnormal
Show

 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
Show

 ZFA:0007029 hindbrain neural keel hindbrain neural keel increased width , abnormal
hindbrain neural keel width , ameliorated
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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