ENSDARG00000014309


Danio rerio

Features
Gene ID: ENSDARG00000014309
  
Biological name :spaw
  
Synonyms : southpaw / spaw
  
Possible biological names infered from orthology : NODAL / nodal growth differentiation factor / P43021 / Q96S42
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 68878124
Gene end: 68885081
  
Corresponding Affymetrix probe sets: Dr.25266.1.S1_at (Zebrafish Array)   NM_180967_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000113959
NCBI entrez gene - 338101     See in Manteia.
RefSeq - NM_180967
RefSeq Peptide - NP_851298
swissprot - F1QX69
ZFIN ID - ZDB-GENE-030219-1
Ensembl - ENSDARG00000014309
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000003209Gallus gallus
 NODALENSG00000156574Homo sapiens
 NodalENSMUSG00000037171Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ndr1 / nodal-related 1 / NODAL* / Q96S42* / P43021* / nodal growth differentiation factor*ENSDARG0000005709643
ndr2 / nodal-related 2 / NODAL* / Q96S42* / nodal growth differentiation factor*ENSDARG0000010127929
gdf3 / P35621 / growth differentiation factor 3 / GDF1* / CERS1* / Q9NR23* / P27544* / P27545* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 1* / Embr...ENSDARG0000003799519
gdf10a / growth differentiation factor 10a / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000009537818
bmp3 / bone morphogenetic protein 3 / P12645* / Q8BHE5* / Bone morphotic protein 3 *ENSDARG0000006052618
gdf10b / growth differentiation factor 10b / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000007389117
inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*ENSDARG0000004077716
tgfb3 / transforming growth factor, beta 3 / P10600*ENSDARG0000001936715
inhbab / inhibin, beta Ab / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000002475915
CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*ENSDARG0000010389215
inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000001267115
INHBE / inhibin beta E subunit / INHBC* / P58166* / P55103* / inhibin beta C subunit*ENSDARG0000010098615
tgfb2l / transforming growth factor, beta 2, likeENSDARG0000007187914
mstna / myostatin a / MSTN* / O14793* / O08689* / myostatin*ENSDARG0000004294714
tgfb1a / transforming growth factor, beta 1a / TGFB1* / P01137* / transforming growth factor beta 1*ENSDARG0000004150214
bmp15 / bone morphogenetic protein 15ENSDARG0000003749114
tgfb2 / transforming growth factor, beta 2 / P27090* / P61812* / Transforming growth factor beta-2 Latency-associated peptide*ENSDARG0000002708714
tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*ENSDARG0000003489513
gdf9 / growth differentiation factor 9 / O60383* / Q07105*ENSDARG0000000322913
gdf11 / growth differentiation factor 11 / O95390* / Q9Z1W4*ENSDARG0000004492413


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035462 determination of left/right asymmetry in diencephalon IMP
 biological_processGO:0035469 determination of pancreatic left/right asymmetry IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048368 lateral mesoderm development IMP
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:0071907 determination of digestive tract left/right asymmetry IMP
 biological_processGO:0071910 determination of liver left/right asymmetry IMP
 biological_processGO:2000223 regulation of BMP signaling pathway involved in heart jogging IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart mislocalised laterally , abnormal
heart mislocalised medially , abnormal
heart quality , abnormal
heart morphology , abnormal
Show

 ZFA:0000115 heart rudiment heart rudiment bilateral symmetry , abnormal
heart rudiment cardioblast anterior-lateral migration process quality , abnormal
heart rudiment endocardial precursor mislocalised , abnormal
heart rudiment myocardial precursor mislocalised , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm spatial pattern , abnormal
lateral plate mesoderm absent , abnormal
Show

 ZFA:0000135 notochord notochord absent , abnormal
Show

 ZFA:0000140 pancreas pancreas symmetry , abnormal
Show

 ZFA:0000149 primitive heart tube primitive heart tube decreased length , abnormal
primitive heart tube bilateral symmetry , abnormal
Show

 ZFA:0000213 habenula habenula symmetry , abnormal
habenula determination of left/right asymmetry in diencephalon process quality , abnormal
habenula determination of left/right symmetry disrupted , abnormal
habenula neurogenesis process quality , abnormal
Show

 ZFA:0000353 fasciculus retroflexus fasciculus retroflexus axon misrouted , abnormal
Show

 ZFA:0000360 heart tube heart tube bilateral symmetry , abnormal
heart tube medial orientation , abnormal
heart tube position , abnormal
heart tube morphology , abnormal
Show

 ZFA:0000509 epithalamus epithalamus determination of left/right symmetry disrupted , abnormal
Show

 ZFA:0001094 whole organism whole organism semi-viable , abnormal
Show

 ZFA:0001360 parapineal organ parapineal organ position , abnormal
Show

 ZFA:0001724 presumptive endocardium presumptive endocardium BMP signaling pathway involved in heart development decreased process quality , abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve blood fluid flow rate , abnormal
atrioventricular valve morphology , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased velocity , abnormal
cardiac muscle cell cell migration involved in heart formation decreased process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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