ENSGALG00000039458


Gallus gallus

Features
Gene ID: ENSGALG00000039458
  
Biological name :GDF8
  
Synonyms : GDF8 / Growth/differentiation factor 8 / O42220
  
Possible biological names infered from orthology : MSTN / myostatin / O08689 / O14793
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 218083
Gene end: 223575
  
Corresponding Affymetrix probe sets: Gga.560.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045551
NCBI entrez gene - 373964     See in Manteia.
RefSeq - NM_001001461
RefSeq Peptide - NP_001001461
swissprot - O42220
swissprot - Q06BS3
Ensembl - ENSGALG00000039458
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mstnaENSDARG00000042947Danio rerio
 mstnbENSDARG00000069133Danio rerio
 MSTNENSG00000138379Homo sapiens
 MstnENSMUSG00000026100Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TGFB3 / transforming growth factor beta 3 / P10600*ENSGALG0000001034627
TGFB2 / P27090* / P61812* / transforming growth factor beta 2* / Transforming growth factor beta-2 Latency-associated peptide*ENSGALG0000000961226
INHBA / inhibin beta A chain precursor / P08476* / Q04998* / Inhibin beta A chain * / inhibin beta A subunit*ENSGALG0000003461622
INHBB / inhibin beta B chain precursor / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*ENSGALG0000002877021
GDF3 / embryonic growth/differentiation factor 1 / GDF1* / CERS1* / P27545* / P27544* / Q9NR23* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 3* / gr...ENSGALG0000000316117
BMP3 / bone morphogenetic protein 3 precursor / P12645* / Q8BHE5* / Bone morphotic protein 3 * / bone morphogenetic protein 3*ENSGALG0000003505216
BMP15 / bone morphogenetic protein 15 precursor ENSGALG0000000474215
GDF10 / growth differentiation factor 10 / P55107* / P97737*ENSGALG0000000598515
NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*ENSGALG0000000320914
GDF9 / growth differentiation factor 9 / O60383* / Q07105*ENSGALG0000002840714
GDF15* / Q99988* / Q9Z0J7* / growth differentiation factor 15* / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA.*ENSGALG000000462787


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR015616  Growth/differentiation factor 8
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007519 skeletal muscle tissue development IEP
 biological_processGO:0009792 embryo development ending in birth or egg hatching IEP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0033002 muscle cell proliferation IDA
 biological_processGO:0033673 negative regulation of kinase activity IEA
 biological_processGO:0040008 regulation of growth NAS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045595 regulation of cell differentiation NAS
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0046716 muscle cell cellular homeostasis IEA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048632 negative regulation of skeletal muscle tissue growth IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:1902723 negative regulation of skeletal muscle satellite cell proliferation ISS
 biological_processGO:1902725 negative regulation of satellite cell differentiation ISS
 biological_processGO:2000818 negative regulation of myoblast proliferation ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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