Manteia - Molecule gene

ENSMUSG00000021765

Mus musculus

Features

Gene ID:	ENSMUSG00000021765

Biological name :	Fst

Synonyms :	follistatin FST315 / Fst

Possible biological names infered from orthology :	follistatin / P19883

Species:	Mus musculus

Chr. number:	13
Strand:	-1
Band:	D2.2
Gene start:	114452262
Gene end:	114458949

Corresponding Affymetrix probe sets:	10412260 (MoGene1.0st) 1421365_at (Mouse Genome 430 2.0 Array) 1434458_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000153451 Ensembl peptide - ENSMUSP00000022287 Ensembl peptide - ENSMUSP00000153365 NCBI entrez gene - 14313 See in Manteia. MGI - MGI:95586 RefSeq - NM_001301373 RefSeq - NM_001301375 RefSeq - NM_008046 RefSeq Peptide - NP_032072 RefSeq Peptide - NP_001288302 RefSeq Peptide - NP_001288304 swissprot - Q8BNY0 swissprot - A0A286YDK1 swissprot - A0A0R4J026 Ensembl - ENSMUSG00000021765

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fsta	ENSDARG00000052846	Danio rerio
fstb	ENSDARG00000057992	Danio rerio
FST	ENSGALG00000014908	Gallus gallus
FST	ENSG00000134363	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Fstl3 / Q9EQC7 / Follistatin-related protein 3 / O95633* / follistatin like 3*	ENSMUSG00000020325	31

Protein motifs (from Interpro)

Interpro ID	Name
IPR002350	Kazal domain
IPR003645	Follistatin-like, N-terminal
IPR015369	Follistatin/Osteonectin EGF domain
IPR017878	TB domain
IPR036058	Kazal domain superfamily
IPR036773	TGF-beta binding (TB) domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0002244	hematopoietic progenitor cell differentiation	IEA
biological_process	GO:0032926	negative regulation of activin receptor signaling pathway	IEA
biological_process	GO:0051798	positive regulation of hair follicle development	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0043395	heparan sulfate proteoglycan binding	IEA
molecular_function	GO:0048185	activin binding	IEA

Pathways (from Reactome)

Pathway description

Antagonism of Activin by Follistatin

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000242	impaired fertilization	"defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv
MP:0000480	increased number of ribs	"greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk,Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst⁺,Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv
MP:0001129	impaired ovarian folliculogenesis	"a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv
MP:0001196	shiny skin	"skin with a glossy or glistening appearance" [J:56641]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001198	tight skin	"skin has a taut, stretched appearance" [J:65038]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001219	thickened epidermis	"increase in the width of the epidermal cell layer in the skin" [J:65146]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Fst^tm1Zuk/Fst⁺,Mstn^tm1Sjl/Mstn⁺ Genetic Background: B6.129-Mstn^tm1Sjl Fst^tm1Zuk
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001750	increased circulating follicle stimulating hormone level	"higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv
MP:0001751	increased circulating luteinizing hormone level	"higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv Allelic Composition: Fst^tm1Alsc/Fst^tm1Alsc Genetic Background: Not Specified
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv
MP:0001928	abnormal ovulation	"aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv Allelic Composition: Fst^tm1Alsc/Fst^tm1Alsc Genetic Background: Not Specified
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002016	ovarian cysts	"cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv
MP:0002098	abnormal vibrissae morphology	"irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002106	abnormal muscle physiology	"anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdk2^tm1.1Jro/Cdk2⁺ Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6
MP:0002680	decreased number of corpora lutea	"fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv
MP:0002682	reduced number of mature ovarian follicles	"fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fst^tm1Alsc/Fst^tm1Alsc Genetic Background: Not Specified
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv
MP:0002823	abnormal rib development	"anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst⁺ Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Fst^tm1Zuk/Fst⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002983	increased retinal ganglion cell number	"greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk,Gdf11^tm1Clf/Gdf11^tm1Clf Genetic Background: involves: 129X1/SvJ * C57BL/6J * CD-1
MP:0003082	abnormal gastrocnemius morphology	"anomaly in the the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cdk2^tm1.1Jro/Cdk2⁺ Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6
MP:0003084	abnormal skeletal muscle fiber morphology	"anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cdk2^tm1.1Jro/Cdk2⁺ Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6
MP:0003345	decreased number of ribs	"fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk,Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst⁺,Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk,Wfikkn1^tm1.1Sjl/Wfikkn1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003346	abnormal pectoral muscle morphology	"anomaly in the two muscles that make up the upper and fore part of the chest that adduct and rotate the arm and lift the ribs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cdk2^tm1.1Jro/Cdk2⁺ Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004201	fetal growth retardation	"slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004246	abnormal extensor digitorum longus morphology	"any structural anomaly of penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdk2^tm1.1Jro/Cdk2⁺ Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6
MP:0004647	decreased lumbar vertebrae number	"reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst⁺ Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Fst^tm1Zuk/Fst⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk,Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004648	decreased thoracic vertebrae number	"reduced number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk,Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst⁺,Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk,Wfikkn1^tm1.1Sjl/Wfikkn1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004650	increased lumbar vertebrae number	"increased number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Fst^tm1Zuk/Fst⁺,Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004791	absent lower incisors	"missing the lower pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004819	decreased skeletal muscle mass	"reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004834	ovary hemorrhage	"presence of bleeding in the ovary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pgf^tm1Pec/Pgf^tm1Pec Genetic Background: involves: 129/Sv
MP:0004981	decreased neuronal precursor cell number	"reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gdf11^tm1Clf/Gdf11^tm1Clf Genetic Background: involves: 129X1/SvJ * CD-1
MP:0005359	growth retardation of incisors	"developmental delay of the growth of the incisors, the long pointed teeth, most anterior and prominent in the jaw " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0006069	abnormal retinal neuronal layer morphology	"malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]	Show Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk,Gdf11^tm1Clf/Gdf11^tm1Clf Genetic Background: involves: 129X1/SvJ * C57BL/6J * CD-1
MP:0006092	abnormal olfactory neuron morphology	"malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]	Show Allelic Composition: Gdf11^tm1Clf/Gdf11^tm1Clf Genetic Background: involves: 129X1/SvJ * CD-1
MP:0008148	abnormal rib-sternum attachment	"any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008507	thin retinal ganglion layer	"reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gdf11^tm1Clf/Gdf11^tm1Clf Genetic Background: involves: 129X1/SvJ * CD-1
MP:0008789	abnormal olfactory epithelium morphology	"any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gdf11^tm1Clf/Gdf11^tm1Clf Genetic Background: involves: 129X1/SvJ * CD-1
MP:0008873	increased sensitivity to xenobiotics	"decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdk2^tm1.1Jro/Cdk2⁺ Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6
MP:0008922	abnormal cervical rib	"alternate location or appearance of a rare supernumerary rib commonly articulating with the seventh cervical vertebrae (above the normal first rib) but not reaching the sternum anteriorly" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk,Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst⁺,Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008995	early reproductive senescence	"loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fst^tm1Alsc/Fst^tm1Alsc Genetic Background: Not Specified
MP:0009361	abnormal primordial ovarian follicle morphology	"any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fst^tm1Alsc/Fst^tm1Alsc Genetic Background: Not Specified
MP:0009362	abnormal primary ovarian follicle morphology	"any structural abnormality in the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fst^tm1Alsc/Fst^tm1Alsc Genetic Background: Not Specified
MP:0009363	abnormal secondary ovarian follicle morphology	"any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fst^tm1Alsc/Fst^tm1Alsc Genetic Background: Not Specified
MP:0009422	decreased gastrocnemius weight	"reduction in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cdk2^tm1.1Jro/Cdk2⁺ Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6
MP:0009431	decreased fetal weight	"reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009894	absent hard palate	"absence of the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones in the adult" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gdf11^tm1Clf/Gdf11^tm1Clf Genetic Background: involves: 129X1/SvJ * CD-1
MP:0010227	decreased quadriceps weight	"reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdk2^tm1.1Jro/Cdk2⁺ Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6
MP:0010239	decreased skeletal muscle weight	"less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdk2^tm1.1Jro/Cdk2⁺ Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst⁺ Genetic Background: B6.129S7-Fst^tm1Zuk Allelic Composition: Fst^tm1Zuk/Fst⁺,Mstn^tm1Sjl/Mstn^tm1Sjl Genetic Background: B6.129-Mstn^tm1Sjl Fst^tm1Zuk Allelic Composition: Fst^tm1Zuk/Fst⁺,Mstn^tm1Sjl/Mstn⁺ Genetic Background: B6.129-Mstn^tm1Sjl Fst^tm1Zuk
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Rps6ka3^tm1Ljg/Rps6ka3^tm1Ljg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Fst^tm1Zuk/Fst^tm1Zuk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000021765	Fst / follistatin FST315 / P19883* / follistatin*	/ complex / reaction
ENSMUSG00000037035	Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*	/ reaction / complex
ENSMUSG00000041324	Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*	/ complex / reaction

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