ENSG00000130513


Homo sapiens

Features
Gene ID: ENSG00000130513
  
Biological name :GDF15
  
Synonyms : GDF15 / growth differentiation factor 15 / Q99988
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.11
Gene start: 18374731
Gene end: 18389176
  
Corresponding Affymetrix probe sets: 221576_at (Human Genome U133 Plus 2.0 Array)   221577_x_at (Human Genome U133 Plus 2.0 Array)   229868_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000469819
Ensembl peptide - ENSP00000470531
Ensembl peptide - ENSP00000252809
NCBI entrez gene - 9518     See in Manteia.
OMIM - 605312
RefSeq - NM_004864
RefSeq Peptide - NP_004855
swissprot - A0A0A0MTT8
swissprot - Q99988
Ensembl - ENSG00000130513
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000046278Gallus gallus
 Gdf15ENSMUSG00000038508Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GDF1 / P27539 / growth differentiation factor 1ENSG0000013028322
CERS1 / P27544 / ceramide synthase 1ENSG0000022380222
GDF10 / P55107 / growth differentiation factor 10ENSG0000026652421
GDF3 / Q9NR23 / growth differentiation factor 3ENSG0000018434419
BMP15 / O95972 / bone morphogenetic protein 15ENSG0000013038518
GDF9 / O60383 / growth differentiation factor 9ENSG0000016440418
INHBE / P58166 / inhibin beta E subunitENSG0000013926917
BMP3 / P12645 / bone morphogenetic protein 3ENSG0000015278517
NODAL / Q96S42 / nodal growth differentiation factorENSG0000015657417
TGFB2 / P61812 / transforming growth factor beta 2ENSG0000009296916
TGFB3 / P10600 / transforming growth factor beta 3ENSG0000011969916
INHBA / P08476 / inhibin beta A subunitENSG0000012264116
TGFB1 / P01137 / transforming growth factor beta 1ENSG0000010532915
INHBC / P55103 / inhibin beta C subunitENSG0000017518914
MSTN / O14793 / myostatinENSG0000013837914
GDF11 / O95390 / growth differentiation factor 11ENSG0000013541413
INHBB / P09529 / inhibin beta B subunitENSG0000016308313


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:1901741 positive regulation of myoblast fusion IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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