ENSG00000164404


Homo sapiens

Features
Gene ID: ENSG00000164404
  
Biological name :GDF9
  
Synonyms : GDF9 / growth differentiation factor 9 / O60383
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.1
Gene start: 132861181
Gene end: 132866884
  
Corresponding Affymetrix probe sets: 221314_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296875
Ensembl peptide - ENSP00000484339
Ensembl peptide - ENSP00000485037
Ensembl peptide - ENSP00000485231
Ensembl peptide - ENSP00000367942
NCBI entrez gene - 2661     See in Manteia.
OMIM - 601918
RefSeq - XM_011543310
RefSeq - NM_001288824
RefSeq - NM_001288825
RefSeq - NM_001288826
RefSeq - NM_001288827
RefSeq - NM_001288828
RefSeq - NM_005260
RefSeq - XM_005271957
RefSeq - XM_006714585
RefSeq - XM_011543308
RefSeq - XM_011543309
RefSeq Peptide - NP_001275756
RefSeq Peptide - NP_005251
RefSeq Peptide - NP_001275755
RefSeq Peptide - NP_001275757
RefSeq Peptide - NP_001275753
RefSeq Peptide - NP_001275754
swissprot - O60383
swissprot - B4DXG3
Ensembl - ENSG00000164404
  
Related genetic diseases (OMIM): 618014 - ?Premature ovarian failure 14, 618014
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf9ENSDARG00000003229Danio rerio
 GDF9ENSGALG00000028407Gallus gallus
 Gdf9ENSMUSG00000018238Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BMP15 / O95972 / bone morphogenetic protein 15ENSG0000013038528
BMP3 / P12645 / bone morphogenetic protein 3ENSG0000015278516
GDF10 / P55107 / growth differentiation factor 10ENSG0000026652416
NODAL / Q96S42 / nodal growth differentiation factorENSG0000015657414
INHBA / P08476 / inhibin beta A subunitENSG0000012264114
GDF1 / P27539 / growth differentiation factor 1ENSG0000013028313
CERS1 / P27544 / ceramide synthase 1ENSG0000022380213
GDF3 / Q9NR23 / growth differentiation factor 3ENSG0000018434413
TGFB3 / P10600 / transforming growth factor beta 3ENSG0000011969913
TGFB2 / P61812 / transforming growth factor beta 2ENSG0000009296913
INHBC / P55103 / inhibin beta C subunitENSG0000017518912
GDF15 / Q99988 / growth differentiation factor 15ENSG0000013051312
MSTN / O14793 / myostatinENSG0000013837912
INHBB / P09529 / inhibin beta B subunitENSG0000016308312
TGFB1 / P01137 / transforming growth factor beta 1ENSG0000010532912
INHBE / P58166 / inhibin beta E subunitENSG0000013926912
GDF11 / O95390 / growth differentiation factor 11ENSG0000013541411


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR015617  Growth differentiation factor-9
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001555 oocyte growth IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007292 female gamete generation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:2000870 regulation of progesterone secretion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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