ENSG00000152785


Homo sapiens

Features
Gene ID: ENSG00000152785
  
Biological name :BMP3
  
Synonyms : BMP3 / bone morphogenetic protein 3 / P12645
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q21.21
Gene start: 81030965
Gene end: 81057531
  
Corresponding Affymetrix probe sets: 208244_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000282701
NCBI entrez gene - 651     See in Manteia.
OMIM - 112263
RefSeq - NM_001201
RefSeq - XM_006714291
RefSeq Peptide - NP_001192
swissprot - P12645
Ensembl - ENSG00000152785
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp3ENSDARG00000060526Danio rerio
 BMP3ENSGALG00000035052Gallus gallus
 Bmp3ENSMUSG00000029335Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GDF10 / P55107 / growth differentiation factor 10ENSG0000026652445
GDF3 / Q9NR23 / growth differentiation factor 3ENSG0000018434417
NODAL / Q96S42 / nodal growth differentiation factorENSG0000015657416
GDF9 / O60383 / growth differentiation factor 9ENSG0000016440416
CERS1 / P27544 / ceramide synthase 1ENSG0000022380216
BMP15 / O95972 / bone morphogenetic protein 15ENSG0000013038516
GDF1 / P27539 / growth differentiation factor 1ENSG0000013028316
TGFB1 / P01137 / transforming growth factor beta 1ENSG0000010532914
INHBE / P58166 / inhibin beta E subunitENSG0000013926914
TGFB3 / P10600 / transforming growth factor beta 3ENSG0000011969914
INHBA / P08476 / inhibin beta A subunitENSG0000012264114
TGFB2 / P61812 / transforming growth factor beta 2ENSG0000009296913
INHBB / P09529 / inhibin beta B subunitENSG0000016308313
MSTN / O14793 / myostatinENSG0000013837912
INHBC / P55103 / inhibin beta C subunitENSG0000017518912
GDF11 / O95390 / growth differentiation factor 11ENSG0000013541412
GDF15 / Q99988 / growth differentiation factor 15ENSG0000013051311


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017197  Bone morphogenetic protein 3/3B
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0070700 BMP receptor binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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