ENSMUSG00000038793


Mus musculus

Features
Gene ID: ENSMUSG00000038793
  
Biological name :Lefty1
  
Synonyms : Left-right determination factor 1 / Lefty1 / Q64280
  
Possible biological names infered from orthology : left-right determination factor 2 / LEFTY2 / O00292 / O75610
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H4
Gene start: 180935022
Gene end: 180938400
  
Corresponding Affymetrix probe sets: 10352314 (MoGene1.0st)   1417638_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041427
NCBI entrez gene - 13590     See in Manteia.
MGI - MGI:107405
RefSeq - NM_010094
RefSeq Peptide - NP_034224
swissprot - Q64280
Ensembl - ENSMUSG00000038793
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lft1ENSDARG00000019920Danio rerio
 lft2ENSDARG00000044059Danio rerio
 LEFTY2ENSGALG00000009256Gallus gallus
 LEFTY1ENSG00000243709Homo sapiens
 LEFTY2ENSG00000143768Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P57785 / Lefty2 / Left-right determination factor 2 / LEFTY1* / O00292* / O75610* / left-right determination factor 1*ENSMUSG0000006665290


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR003942  Left- Right determination factor
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IDA
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0009948 anterior/posterior axis specification IGI
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0016049 cell growth IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0042074 cell migration involved in gastrulation IGI
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:1900108 negative regulation of nodal signaling pathway IDA
 biological_processGO:1900124 negative regulation of nodal receptor complex assembly IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0038100 nodal binding IPI


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000542 left-sided isomerism "the relative symmetry of the organs of the thorax and abdomen as indicated by both atria displaying the morphology of the left atrium" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0002766 situs inversus "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Lefty1tm1Sla/Lefty1tm1Sla
Genetic Background: involves: 129/Sv * CD-1

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0006123 tricuspid valve atresia "congenital closure of the tricuspid valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0008461 left atrial isomerism "anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the left side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0010413 complete atrioventricular septal defect "a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0010425 abnormal heart and great vessel attachment "any anomaly in the in the position or pattern of the connection site of the heart to any of the primary vessels, including the superior vena cavae, inferior vena cavae, pulmonary artery, pulmonary veins, and aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0010668 abnormal hepatic portal vein morphology "any structural anomaly of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, and then divides into the right and left branches which ramify with the liver; the hepatic portal vein carries venous blood from the GI tract, spleen and pancreas to the liver" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla
Genetic Background: involves: 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0011199 abnormal amniotic cavity morphology "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0011255 abnormal anterior visceral endoderm cell migration "any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Lyn/Celsr1/EGFP)Rodr/Gt(ROSA)26Sor+
Genetic Background: involves: FVB/N

 MP:0011327 abnormal left renal vein morphology "any structural anomaly of the longer of the two renal veins that receives blood from the left kidney; the left renal vein usually receives the left inferior phrenic vein, the left suprarenal vein, the left gonadal vein (left testicular vein in males, left ovarian vein in females) and the left second lumbar vein whereas these veins on the right side drain directly into the inferior vena cava" [ISBN:0-683-40008-8]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0011569 abnormal azygos vein morphology "any structural anomaly of the unpaired vein which in humans arises from the right ascending lumbar vein or the vena cava, enters the thorax through the aortic orifice in the diaphragm, and terminates in the superior vena cava; unlike humans, mice have a single and left-sided azygos vein that develops from the paired embryonic cardinal venous system and drains most of the right and left thoracic walls into the left anterior vena cava" [MGI:anna]
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Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla
Genetic Background: involves: 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026124 Cfc1 / P97766 / Cryptic protein / CFC1B* / P0CG36* / P0CG37* / cripto, FRL-1, cryptic family 1* / cripto, FRL-1, cryptic family 1B*  / complex / reaction
 ENSMUSG00000037171 Nodal / P43021 / Q96S42* / nodal growth differentiation factor*  / reaction / complex






 

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