ENSDARG00000019920


Danio rerio

Features
Gene ID: ENSDARG00000019920
  
Biological name :lft1
  
Synonyms : lefty1 / lft1
  
Possible biological names infered from orthology : left-right determination factor 1 / left-right determination factor 2 / LEFTY2 / O00292 / O75610 / P57785 / Q64280
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 35073981
Gene end: 35076387
  
Corresponding Affymetrix probe sets: Dr.8208.1.S1_at (Zebrafish Array)   NM_130960_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000005312
NCBI entrez gene - 30145     See in Manteia.
RefSeq - NM_130960
RefSeq Peptide - NP_571035
swissprot - Q9W6I6
ZFIN ID - ZDB-GENE-990630-10
Ensembl - ENSDARG00000019920
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LEFTY2ENSGALG00000009256Gallus gallus
 LEFTY1ENSG00000243709Homo sapiens
 LEFTY2ENSG00000143768Homo sapiens
 Lefty1ENSMUSG00000038793Mus musculus
 Lefty2ENSMUSG00000066652Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lft2 / lefty2 / LEFTY1* / Q64280* / O75610* / P57785* / O00292* / left-right determination factor 1* / left-right determination factor 2*ENSDARG0000004405969


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR003942  Left- Right determination factor
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035462 determination of left/right asymmetry in diencephalon IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart size , ameliorated
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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