ENSG00000243709


Homo sapiens

Features
Gene ID: ENSG00000243709
  
Biological name :LEFTY1
  
Synonyms : left-right determination factor 1 / LEFTY1 / O75610
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q42.12
Gene start: 225886282
Gene end: 225911382
  
Corresponding Affymetrix probe sets: 206268_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000272134
Ensembl peptide - ENSP00000479837
NCBI entrez gene - 10637     See in Manteia.
OMIM - 603037
RefSeq - NM_020997
RefSeq Peptide - NP_066277
swissprot - A0A087WW09
swissprot - O75610
Ensembl - ENSG00000243709
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lft1ENSDARG00000019920Danio rerio
 lft2ENSDARG00000044059Danio rerio
 LEFTY2ENSGALG00000009256Gallus gallus
 Lefty1ENSMUSG00000038793Mus musculus
 Lefty2ENSMUSG00000066652Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LEFTY2 / O00292 / left-right determination factor 2ENSG0000014376896


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR003942  Left- Right determination factor
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0003007 heart morphogenesis ISS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0016049 cell growth IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Regulation of signaling by NODAL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136698 CFC1 / P0CG37 / cripto, FRL-1, cryptic family 1  / complex / reaction
 ENSG00000123612 ACVR1C / Q8NER5 / activin A receptor type 1C  / complex / reaction
 ENSG00000121989 ACVR2A / P27037 / activin A receptor type 2A  / complex / reaction
 ENSG00000135503 ACVR1B / P36896 / activin A receptor type 1B  / reaction / complex
 ENSG00000241186 TDGF1 / P13385 / teratocarcinoma-derived growth factor 1  / complex / reaction
 ENSG00000156574 NODAL / Q96S42 / nodal growth differentiation factor  / complex / reaction
 ENSG00000114739 ACVR2B / Q13705 / activin A receptor type 2B  / reaction / complex






 

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