ENSDARG00000035095


Danio rerio

Features
Gene ID: ENSDARG00000035095
  
Biological name :tdgf1
  
Synonyms : tdgf1 / teratocarcinoma-derived growth factor 1
  
Possible biological names infered from orthology : CFC1 / CFC1B / cripto, FRL-1, cryptic family 1 / cripto, FRL-1, cryptic family 1B / Cryptic protein / P0CG36 / P0CG37 / P13385 / P97766
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 1955475
Gene end: 1961930
  
Corresponding Affymetrix probe sets: Dr.581.1.S1_at (Zebrafish Array)   NM_131092_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000106724
Ensembl peptide - ENSDARP00000042440
NCBI entrez gene - 30304     See in Manteia.
RefSeq - NM_001328408
RefSeq - NM_131092
RefSeq Peptide - NP_001315337
RefSeq Peptide - NP_571167
swissprot - A7MCB2
swissprot - F1Q691
ZFIN ID - ZDB-GENE-990415-198
Ensembl - ENSDARG00000035095
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CFC1ENSGALG00000012623Gallus gallus
 CFC1ENSG00000136698Homo sapiens
 CFC1BENSG00000152093Homo sapiens
 TDGF1ENSG00000241186Homo sapiens
 Cfc1ENSMUSG00000026124Mus musculus
 Tdgf1ENSMUSG00000032494Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013032  EGF-like, conserved site
 IPR019011  Cryptic/Cripto, CFC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001706 endoderm formation IMP
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0001756 somitogenesis IGI
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007398 ectoderm development IMP
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007498 mesoderm development IGI
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008354 germ cell migration IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0021501 prechordal plate formation IMP
 biological_processGO:0021508 floor plate formation IMP
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021854 hypothalamus development IMP
 biological_processGO:0021999 neural plate anterior/posterior regionalization IGI
 biological_processGO:0030325 adrenal gland development IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0030903 notochord development IGI
 biological_processGO:0033504 floor plate development IMP
 biological_processGO:0035775 pronephric glomerulus morphogenesis IMP
 biological_processGO:0046619 optic placode formation involved in camera-type eye formation IMP
 biological_processGO:0048339 paraxial mesoderm development IGI
 biological_processGO:0048382 mesendoderm development IGI
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0048570 notochord morphogenesis IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0050930 induction of positive chemotaxis IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060975 cardioblast migration to the midline involved in heart field formation IMP
 biological_processGO:0061053 somite development IGI
 biological_processGO:0072045 convergent extension involved in nephron morphogenesis IMP
 biological_processGO:0090008 hypoblast development IMP
 cellular_componentGO:0009897 external side of plasma membrane IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000004 anterior axial hypoblast anterior axial hypoblast increased thickness , abnormal
Show

 ZFA:0000008 brain brain morphology , abnormal
brain decreased size , abnormal
Show

 ZFA:0000012 central nervous system central nervous system ventral region decreased size , abnormal
Show

 ZFA:0000017 endoderm endoderm aplastic , abnormal
endoderm endodermal cell decreased amount , abnormal
endoderm absent , abnormal
endoderm decreased size , abnormal
Show

 ZFA:0000022 floor plate floor plate quality , abnormal
floor plate decreased size , abnormal
floor plate absent , abnormal
Show

 ZFA:0000023 forerunner cell group forerunner cell group absent , abnormal
Show

 ZFA:0000026 hatching gland hatching gland quality , abnormal
hatching gland aplastic , abnormal
Show

 ZFA:0000032 hypothalamus hypothalamus decreased size , abnormal
Show

 ZFA:0000035 lens lens fused with lens , abnormal
lens aplastic , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
Show

 ZFA:0000038 margin margin dorsal region absent , abnormal
margin decreased amount , abnormal
Show

 ZFA:0000041 mesoderm mesoderm morphology , abnormal
mesoderm malformed , abnormal
mesoderm aplastic , abnormal
Show

 ZFA:0000048 olfactory placode olfactory placode aplastic , abnormal
Show

 ZFA:0000058 polster polster absent , abnormal
polster aplastic , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate morphology , abnormal
prechordal plate aplastic , abnormal
prechordal plate aplastic/hypoplastic , abnormal
prechordal plate decreased size , abnormal
Show

 ZFA:0000071 shield shield morphology , abnormal
shield absent , abnormal
shield poorly differentiated , abnormal
Show

 ZFA:0000075 spinal cord spinal cord morphology , abnormal
Show

 ZFA:0000077 tail bud tail bud increased size , abnormal
Show

 ZFA:0000079 telencephalon telencephalon aplastic , abnormal
Show

 ZFA:0000092 axis axis decreased length , abnormal
Show

 ZFA:0000101 diencephalon diencephalon dopaminergic neuron decreased amount , abnormal
Show

 ZFA:0000106 extension extension aplastic , abnormal
extension decreased length , abnormal
extension increased thickness , abnormal
Show

 ZFA:0000107 eye eye quality , abnormal
eye fused with eye , abnormal
eye malformed , abnormal
eye mislocalised medially , abnormal
eye decreased amount , abnormal
eye mislocalised , abnormal
Show

 ZFA:0000109 forebrain forebrain morphology , abnormal
forebrain aplastic , abnormal
Show

 ZFA:0000111 germ ring germ ring absent , abnormal
germ ring poorly differentiated , abnormal
Show

 ZFA:0000112 gut gut aplastic , abnormal
gut physical object quality , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
Show

 ZFA:0000128 midbrain midbrain posterior region increased amount , abnormal
Show

 ZFA:0000131 neural keel neural keel malformed , abnormal
Show

 ZFA:0000132 neural plate neural plate cell migration process quality , abnormal
neural plate cell motility process quality , abnormal
Show

 ZFA:0000135 notochord notochord decreased thickness , abnormal
notochord anterior region absent , abnormal
notochord curved ventral , abnormal
notochord morphology , abnormal
notochord undulate , abnormal
Show

 ZFA:0000137 optic stalk optic stalk morphology , abnormal
Show

 ZFA:0000152 retina retina stratification , abnormal
retina aplastic , abnormal
Show

 ZFA:0000155 somite somite increased width , abnormal
Show

 ZFA:0000265 presumptive dorsal mesoderm presumptive dorsal mesoderm morphology , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000360 heart tube heart tube bilateral symmetry , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0001032 rhombomere 4 rhombomere 4 morphology , abnormal
Show

 ZFA:0001065 lateral mesoderm lateral mesoderm mesodermal cell misrouted , abnormal
Show

 ZFA:0001094 whole organism whole organism has fewer parts of type cell , abnormal
whole organism has extra parts of type cell , abnormal
whole organism altered number of cell , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism anterior-posterior axis decreased length , abnormal
whole organism anterior-posterior axis curved ventral , abnormal
whole organism increased amount , abnormal
whole organism decreased amount , abnormal
whole organism wholly ventralized , abnormal
whole organism anterior-posterior axis curved , abnormal
Show

 ZFA:0001114 head head degenerate , abnormal
head morphology , abnormal
head hypoplastic , abnormal
head shape , abnormal
head mesoderm aplastic , abnormal
head mesoderm absent , abnormal
head decreased size , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
trunk duplicated , abnormal
trunk anterior-posterior axis bifurcated , abnormal
trunk mesoderm aplastic , abnormal
trunk mesoderm absent , abnormal
Show

 ZFA:0001117 post-vent region post-vent region malformed , abnormal
post-vent region structure , abnormal
post-vent region curved ventral , abnormal
Show

 ZFA:0001120 neuroectoderm neuroectoderm morphology , abnormal
neuroectoderm anterior region increased distribution , abnormal
neuroectoderm anterior region decreased amount , abnormal
neuroectoderm posterior region decreased distribution , abnormal
neuroectoderm anterior region spatial pattern , abnormal
neuroectoderm posterior region mislocalised , abnormal
Show

 ZFA:0001135 neural tube neural tube morphology , abnormal
neural tube cell division arrested , abnormal
neural tube cell division cellular spatiotemporal quality , abnormal
Show

 ZFA:0001177 roof plate spinal cord region roof plate spinal cord region cell projection decreased length , abnormal
Show

 ZFA:0001257 medial floor plate medial floor plate aplastic , abnormal
Show

 ZFA:0001294 epibranchial placode epibranchial placode morphology , abnormal
Show

 ZFA:0001295 facial placode facial placode morphology , abnormal
Show

 ZFA:0001296 glossopharyngeal placode glossopharyngeal placode morphology , abnormal
Show

 ZFA:0001359 pineal complex pineal complex shape , abnormal
pineal complex elongated , abnormal
pineal complex split bilaterally , abnormal
Show

 ZFA:0001360 parapineal organ parapineal organ determination of left/right symmetry disrupted , abnormal
Show

 ZFA:0001378 axial hypoblast axial hypoblast absent , abnormal
Show

 ZFA:0001390 pancreatic bud pancreatic bud lacks all parts of type pancreatic B cell , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001678 immature eye immature eye malformed , abnormal
immature eye decreased amount , abnormal
Show

 ZFA:0005738 intestinal bulb primordium intestinal bulb primordium bilateral symmetry , abnormal
Show

 ZFA:0007026 forebrain neural keel forebrain neural keel antero-dorsal region increased size , abnormal
Show

 ZFA:0007064 mandibular neural crest mandibular neural crest fused with hyoid neural crest , abnormal
Show

 ZFA:0009151 hatching gland cell hatching gland cell absent , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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