ENSGALG00000041432


Gallus gallus

Features
Gene ID: ENSGALG00000041432
  
Biological name :STUB1
  
Synonyms : Q5ZHY5 / STIP1 homology and U box-containing protein 1 / STUB1
  
Possible biological names infered from orthology : Q9UNE7 / Q9WUD1
  
Species: Gallus gallus
  
Chr. number: 14
Strand: 1
Band:
Gene start: 13200580
Gene end: 13204382
  
Corresponding Affymetrix probe sets: Gga.6217.1.S1_at (Chicken Array)   Gga.6217.2.S1_s_at (Chicken Array)   GgaAffx.13102.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057641
NCBI entrez gene - 426918     See in Manteia.
RefSeq - NM_001031406
RefSeq - XM_015294667
RefSeq Peptide - NP_001026577
swissprot - Q5ZHY5
Ensembl - ENSGALG00000041432
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stub1ENSDARG00000045228Danio rerio
 STUB1ENSG00000103266Homo sapiens
 Stub1ENSMUSG00000039615Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SGTB / small glutamine-rich tetratricopeptide repeat-containing protein beta / Q8VD33* / Q96EQ0* / small glutamine rich tetratricopeptide repeat containing beta*ENSGALG0000001476812
SGTA / small glutamine rich tetratricopeptide repeat containing alpha / O43765* / Q8BJU0* / small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha*ENSGALG0000001406710
ENSGALG000000078337


Protein motifs (from Interpro)
Interpro ID Name
 IPR003613  U box domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006515 protein quality control for misfolded or incompletely synthesized proteins IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030579 ubiquitin-dependent SMAD protein catabolic process IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0031943 regulation of glucocorticoid metabolic process IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0071218 cellular response to misfolded protein IEA
 biological_processGO:0090035 positive regulation of chaperone-mediated protein complex assembly IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0042405 nuclear inclusion body IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0030911 TPR domain binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0051787 misfolded protein binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of TGF-beta receptor signaling
Downregulation of ERBB2 signaling
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000040276 RUNX2 / runt related transcription factor 2 / Q08775* / Q13950*  / complex / reaction






 

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