ENSDARG00000045228


Danio rerio

Features
Gene ID: ENSDARG00000045228
  
Biological name :stub1
  
Synonyms : STIP1 homology and U-Box containing protein 1 / stub1
  
Possible biological names infered from orthology : Q9UNE7 / Q9WUD1
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 39656834
Gene end: 39667465
  
Corresponding Affymetrix probe sets: Dr.25565.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000114876
Ensembl peptide - ENSDARP00000121736
Ensembl peptide - ENSDARP00000118937
Ensembl peptide - ENSDARP00000066499
NCBI entrez gene - 324243     See in Manteia.
swissprot - E9QEY7
swissprot - E9QDW8
swissprot - F1Q8K3
swissprot - Q7ZTZ6
ZFIN ID - ZDB-GENE-030131-2963
Ensembl - ENSDARG00000045228
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STUB1ENSGALG00000041432Gallus gallus
 STUB1ENSG00000103266Homo sapiens
 Stub1ENSMUSG00000039615Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sgta / small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha / O43765* / Q8BJU0* / small glutamine rich tetratricopeptide repeat containing alpha*ENSDARG0000001994111
ttc12 / tetratricopeptide repeat domain 12 / Q8BW49* / Q9H892*ENSDARG0000005689610
sgtb / small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta / Q96EQ0* / Q8VD33* / small glutamine rich tetratricopeptide repeat containing beta* / Small glutamine-rich tetra...ENSDARG0000001676910


Protein motifs (from Interpro)
Interpro ID Name
 IPR003613  U box domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030579 ubiquitin-dependent SMAD protein catabolic process ISS
 biological_processGO:0031398 positive regulation of protein ubiquitination ISS
 biological_processGO:0031943 regulation of glucocorticoid metabolic process ISS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0030544 Hsp70 protein binding ISS
 molecular_functionGO:0030911 TPR domain binding ISS
 molecular_functionGO:0046332 SMAD binding ISS
 molecular_functionGO:0051879 Hsp90 protein binding ISS


Pathways (from Reactome)
Pathway description
Downregulation of TGF-beta receptor signaling
Downregulation of ERBB2 signaling
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / reaction / complex
 ENSDARG00000040261 runx2a / runt-related transcription factor 2a / RUNX2* / Q08775* / Q13950* / runt related transcription factor 2*  / reaction / complex






 

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