ENSMUSG00000019789


Mus musculus

Features
Gene ID: ENSMUSG00000019789
  
Biological name :Hey2
  
Synonyms : Hairy/enhancer-of-split related with YRPW motif protein 2 / Hey2 / Q9QUS4
  
Possible biological names infered from orthology : hes related family bHLH transcription factor with YRPW motif 2 / Q9UBP5
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A4
Gene start: 30832359
Gene end: 30842801
  
Corresponding Affymetrix probe sets: 10368556 (MoGene1.0st)   1418106_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019924
NCBI entrez gene - 15214     See in Manteia.
MGI - MGI:1341884
RefSeq - NM_013904
RefSeq Peptide - NP_038932
swissprot - Q0VGJ1
swissprot - Q9QUS4
Ensembl - ENSMUSG00000019789
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hey2ENSDARG00000013441Danio rerio
 HEY2ENSGALG00000034716Gallus gallus
 HEY2ENSG00000135547Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hey1 / hes related family bHLH transcription factor with YRPW motif 1 / Q9Y5J3*ENSMUSG0000004028950
Heyl / Q9DBX7 / Hairy/enhancer-of-split related with YRPW motif-like protein / Q9NQ87* / hes related family bHLH transcription factor with YRPW motif-like*ENSMUSG0000003274437
Helt / Q7TS99 / Hairy and enhancer of split-related protein HELT / A6NFD8* / helt bHLH transcription factor*ENSMUSG0000004717118


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0001570 vasculogenesis IGI
 biological_processGO:0003150 muscular septum morphogenesis IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003171 atrioventricular valve development IMP
 biological_processGO:0003184 pulmonary valve morphogenesis IMP
 biological_processGO:0003186 tricuspid valve morphogenesis IMP
 biological_processGO:0003195 tricuspid valve formation IMP
 biological_processGO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation IGI
 biological_processGO:0003208 cardiac ventricle morphogenesis IMP
 biological_processGO:0003214 cardiac left ventricle morphogenesis IMP
 biological_processGO:0003215 cardiac right ventricle morphogenesis IMP
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IGI
 biological_processGO:0003300 cardiac muscle hypertrophy IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009948 anterior/posterior axis specification IGI
 biological_processGO:0010460 positive regulation of heart rate IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IMP
 biological_processGO:0014031 mesenchymal cell development IMP
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IDA
 biological_processGO:0035910 ascending aorta morphogenesis IMP
 biological_processGO:0035912 dorsal aorta morphogenesis IGI
 biological_processGO:0036304 umbilical cord morphogenesis IGI
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045607 regulation of inner ear auditory receptor cell differentiation IGI
 biological_processGO:0045746 negative regulation of Notch signaling pathway IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0055015 ventricular cardiac muscle cell development IMP
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IMP
 biological_processGO:0060347 heart trabecula formation IMP
 biological_processGO:0060411 cardiac septum morphogenesis IMP
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060413 atrial septum morphogenesis IMP
 biological_processGO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter ISO
 biological_processGO:0060716 labyrinthine layer blood vessel development IGI
 biological_processGO:0060840 artery development IGI
 biological_processGO:0060842 arterial endothelial cell differentiation IGI
 biological_processGO:0060948 cardiac vascular smooth muscle cell development IMP
 biological_processGO:0060977 coronary vasculature morphogenesis IMP
 biological_processGO:0061156 pulmonary artery morphogenesis IMP
 biological_processGO:0061314 Notch signaling involved in heart development IC
 biological_processGO:0065004 protein-DNA complex assembly IDA
 biological_processGO:0090102 cochlea development IMP
 biological_processGO:0097084 vascular smooth muscle cell development IEA
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IDA
 biological_processGO:2001212 regulation of vasculogenesis IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016580 Sin3 complex IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IMP
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0035939 microsatellite binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Hey2tm1Uts/Hey2tm1Uts
Genetic Background: either: (involves: 129X1/SvJ) or (involves: C57BL/6)

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: B6.129P2-Hey2tm1Gess

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: B6.Cg-Hey2tm1Mtc

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: C.Cg-Hey2tm1Mtc

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: B6.Cg-Hey2tm1Mtc

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hey2tm2.1Mtc/Hey2tm2.1Mtc,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0001725 abnormal umbilical cord "malformed connective stalk between the fetus and the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Keap1tm1Mym/Keap1tm2Mym,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002624 abnormal tricuspid valve morphology "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: B6.Cg-Hey2tm1Mtc

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Hey2tm1Uts/Hey2tm1Uts
Genetic Background: either: (involves: 129X1/SvJ) or (involves: C57BL/6)

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: B6.Cg-Hey2tm1Mtc

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: C.Cg-Hey2tm1Mtc

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: B6.Cg-Hey2tm1Mtc

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm2.1Mtc/Hey2tm2.1Mtc,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0003410 abnormal artery development "anomaly in the process of forming the blood vessels that carry blood away from the heart" [J:94740, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm2.1Mtc/Hey2tm2.1Mtc,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0004225 patent foramen ovale "incomplete closure of the atrial septum after birth, resulting in a flap or a valve-like opening in the atrial septal wall" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: B6.129P2-Hey2tm1Gess

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm2.1Mtc/Hey2tm2.1Mtc,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Hey2tm2.1Mtc/Hey2tm2.1Mtc,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: B6.Cg-Hey2tm1Mtc

Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006044 tricuspid valve insufficiency "the tricuspid valve does not close tightly enough to prevent leakage" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006045 mitral valve insufficiency "the mitral valve does not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006046 atrioventricular valve insufficiency "the atrioventricular valves do not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006047 aortic valve insufficiency "the aortic valve does not close tightly enough to prevent leakage. " [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006113 abnormal heart septum morphology "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: C.Cg-Hey2tm1Mtc

 MP:0006117 aortic valve stenosis "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006123 tricuspid valve atresia "congenital closure of the tricuspid valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Uts/Hey2tm1Uts
Genetic Background: either: (involves: 129X1/SvJ) or (involves: C57BL/6)

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: B6.129P2-Hey2tm1Gess

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: C.Cg-Hey2tm1Mtc

 MP:0006124 tricuspid valve stenosis "abnormal narrowing of the tricuspid valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: B6.129P2-Hey2tm1Gess

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: C.Cg-Hey2tm1Mtc

 MP:0006128 pulmonary valve stenosis "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Uts/Hey2tm1Uts
Genetic Background: either: (involves: 129X1/SvJ) or (involves: C57BL/6)

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm2.1Mtc/Hey2tm2.1Mtc,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0006341 small first branchial arch "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006344 small second branchial arch "reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0008824 absent ventricular membranous septum "absence of the membranous portion of the wall between the two lower chambers of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd

 MP:0010017 visceral vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: B6.Cg-Hey2tm1Mtc

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: C.Cg-Hey2tm1Mtc

Allelic Composition: Hey2tm2Eno/Hey2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Hey2tm2Eno/Hey2tm2Eno
Genetic Background: 129-Hey2tm2Eno

Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Hey2tm1Uts/Hey2tm1Uts
Genetic Background: either: (involves: 129X1/SvJ) or (involves: C57BL/6)

 MP:0010405 ostium secundum atrial septal defect "large interatrial communication (atrial septal defect) through the center of the wall between the atria at the site of the foramen ovale and the ostium secundum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010406 absent atrial septum "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hey2tm1Uts/Hey2tm1Uts
Genetic Background: either: (involves: 129X1/SvJ) or (involves: C57BL/6)

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: B6.129P2-Hey2tm1Gess

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Hey2tm1Uts/Hey2tm1Uts
Genetic Background: either: (involves: 129X1/SvJ) or (involves: C57BL/6)

 MP:0010432 common ventricle "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010457 pulmonary artery stenosis "constriction or narrowing of the pulmonary artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Uts/Hey2tm1Uts
Genetic Background: either: (involves: 129X1/SvJ) or (involves: C57BL/6)

 MP:0010499 abnormal ventricle myocardium morphology "any structural anomaly of the ventricular part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010594 thick aortic valve "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010595 abnormal aortic valve cusp morphology "any structural anomaly of the three fibrous triangular components and associated flap of the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010601 thick pulmonary valve "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010602 abnormal pulmonary valve cusp morphology "any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey2tm1Uts/Hey2tm1Uts
Genetic Background: either: (involves: 129X1/SvJ) or (involves: C57BL/6)

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010617 thick mitral valve cusps 
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: B6.Cg-Hey2tm1Mtc

 MP:0010997 decreased aorta wall thickness "decreased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: B6.Cg-Hey2tm1Mtc

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
Show

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: B6.Cg-Hey2tm1Mtc

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: C.Cg-Hey2tm1Mtc

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hey2tm1Uts/Hey2tm1Uts
Genetic Background: either: (involves: 129X1/SvJ) or (involves: C57BL/6)

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: B6.129P2-Hey2tm1Gess

Allelic Composition: Hey2tm1Gess/Hey2tm1Gess
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hey2tm2Eno/Hey2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Hey2tm2Eno/Hey2tm2Eno
Genetic Background: 129-Hey2tm2Eno

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Hey2tm1Eno/Hey2tm2Eno,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction / complex






 

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