ENSMUSG00000040289


Mus musculus

Features
Gene ID: ENSMUSG00000040289
  
Biological name :Hey1
  
Synonyms : hes related family bHLH transcription factor with YRPW motif 1 / Hey1
  
Possible biological names infered from orthology : Q9Y5J3
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A1
Gene start: 8663359
Gene end: 8667256
  
Corresponding Affymetrix probe sets: 10497203 (MoGene1.0st)   1415999_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038014
NCBI entrez gene - 15213     See in Manteia.
MGI - MGI:1341800
RefSeq - NM_010423
RefSeq Peptide - NP_034553
swissprot - Q9QUM5
Ensembl - ENSMUSG00000040289
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hey1ENSDARG00000070538Danio rerio
 HEY1ENSGALG00000035031Gallus gallus
 HEY1ENSG00000164683Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hey2 / Q9QUS4 / Hairy/enhancer-of-split related with YRPW motif protein 2 / Q9UBP5* / hes related family bHLH transcription factor with YRPW motif 2*ENSMUSG0000001978956
Heyl / Q9DBX7 / Hairy/enhancer-of-split related with YRPW motif-like protein / Q9NQ87* / hes related family bHLH transcription factor with YRPW motif-like*ENSMUSG0000003274442
Helt / Q7TS99 / Hairy and enhancer of split-related protein HELT / A6NFD8* / helt bHLH transcription factor*ENSMUSG0000004717123


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0035939 microsatellite binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA

Allelic Composition: Hey1tm1Gess/Hey1tm1Gess,Heyltm1Gess/Heyltm1Gess
Genetic Background: either: B6.129-Hey1tm1Gess Heyltm1Gess or (involves: 129 * C57BL/6)

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0001725 abnormal umbilical cord "malformed connective stalk between the fetus and the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Robo2tm1Mrt/Robo2tm1Mrt,Robo3tm1Matl/Robo3tm1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Hey1tm2Gess/Hey1tm2Gess
Genetic Background: B6.129-Hey1tm2Gess

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hey1tm1Gess/Hey1tm1Gess,Heyltm1Gess/Heyltm1Gess
Genetic Background: either: B6.129-Hey1tm1Gess Heyltm1Gess or (involves: 129 * C57BL/6)

 MP:0003410 abnormal artery development "anomaly in the process of forming the blood vessels that carry blood away from the heart" [J:94740, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003833 decreased number of satellite cells "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004232 decreased muscle weight "less than average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0006006 increased sensory neuron number "greater than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adip1SM/J/?,Capn10tm1Chev/Capn10+
Genetic Background: (B6.129-Capn10tm1Chev x SM/J)F1

 MP:0006128 pulmonary valve stenosis "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hey1tm1Gess/Hey1tm1Gess,Heyltm1Gess/Heyltm1Gess
Genetic Background: either: B6.129-Hey1tm1Gess Heyltm1Gess or (involves: 129 * C57BL/6)

 MP:0006341 small first branchial arch "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006344 small second branchial arch "reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm1Gess/Hey1tm1Gess,Heyltm1Gess/Heyltm1Gess
Genetic Background: either: B6.129-Hey1tm1Gess Heyltm1Gess or (involves: 129 * C57BL/6)

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey1tm1Gess/Hey1tm1Gess,Heyltm1Gess/Heyltm1Gess
Genetic Background: either: B6.129-Hey1tm1Gess Heyltm1Gess or (involves: 129 * C57BL/6)

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009410 abnormal skeletal muscle satellite cell proliferation "anomaly in the ability of unfused cells in skeltal muscle to undergo expansion by cell division, usually triggered by injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010406 absent atrial septum "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
Show

Allelic Composition: Hey1tm1Gess/Hey1tm1Gess,Heyltm1Gess/Heyltm1Gess
Genetic Background: either: B6.129-Hey1tm1Gess Heyltm1Gess or (involves: 129 * C57BL/6)

 MP:0010432 common ventricle "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010585 abnormal conotruncal ridge morphology "any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
Show

Allelic Composition: Hey1tm1Gess/Hey1tm1Gess,Heyltm1Gess/Heyltm1Gess
Genetic Background: either: B6.129-Hey1tm1Gess Heyltm1Gess or (involves: 129 * C57BL/6)

 MP:0010601 thick pulmonary valve "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hey1tm1Gess/Hey1tm1Gess,Heyltm1Gess/Heyltm1Gess
Genetic Background: either: B6.129-Hey1tm1Gess Heyltm1Gess or (involves: 129 * C57BL/6)

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hey1tm1Gess/Hey1tm1Gess,Heyltm1Gess/Heyltm1Gess
Genetic Background: either: B6.129-Hey1tm1Gess Heyltm1Gess or (involves: 129 * C57BL/6)

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Rps6ka3tm1.1Kry/Rps6ka3+
Genetic Background: involves: 129X1/SvJ

 MP:0013239 impaired skeletal muscle regeneration "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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