ENSDARG00000013441


Danio rerio

Features
Gene ID: ENSDARG00000013441
  
Biological name :hey2
  
Synonyms : hes-related family bHLH transcription factor with YRPW motif 2 / hey2 / Q9I9L0
  
Possible biological names infered from orthology : Hairy/enhancer-of-split related with YRPW motif protein 2 / Q9QUS4 / Q9UBP5
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 39588897
Gene end: 39596338
  
Corresponding Affymetrix probe sets: Dr.8232.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000002357
NCBI entrez gene - 58146     See in Manteia.
RefSeq - NM_131622
RefSeq Peptide - NP_571697
swissprot - Q9I9L0
ZFIN ID - ZDB-GENE-000526-1
Ensembl - ENSDARG00000013441
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HEY2ENSGALG00000034716Gallus gallus
 HEY2ENSG00000135547Homo sapiens
 Hey2ENSMUSG00000019789Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hey1 / Q8AXV6 / hes-related family bHLH transcription factor with YRPW motif 1 / Q9Y5J3*ENSDARG0000007053847
heyl / Q8AXV5 / hes-related family bHLH transcription factor with YRPW motif-like / Q9DBX7* / Q9NQ87* / Hairy/enhancer-of-split related with YRPW motif-like protein *ENSDARG0000005579841
helt / Q6QB00 / helt bHLH transcription factor / A6NFD8* / Q7TS99* / Hairy and enhancer of split-related protein HELT *ENSDARG0000005640019


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0035912 dorsal aorta morphogenesis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IGI
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0060840 artery development IMP
 biological_processGO:0060853 Notch signaling pathway involved in arterial endothelial cell fate commitment IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000005 artery artery absent , abnormal
Show

 ZFA:0000008 brain brain hemorrhagic , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta closed , abnormal
dorsal aorta collapsed , abnormal
dorsal aorta aplastic , abnormal
dorsal aorta absent , abnormal
dorsal aorta anatomical region absent , abnormal
dorsal aorta vascular associated smooth muscle cell absent , abnormal
dorsal aorta vascular associated smooth muscle cell decreased amount , abnormal
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 ZFA:0000082 vein vein morphology , abnormal
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 ZFA:0000114 heart heart quality , abnormal
heart cardiac muscle cell increased size , abnormal
heart increased size , abnormal
heart sarcomere increased size , abnormal
Show

 ZFA:0000471 atrium atrium increased size , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein morphology , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature broken , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel collapsed , abnormal
intersegmental vessel absent , abnormal
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 ZFA:0001346 interrenal primordium interrenal primordium centered , abnormal
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 ZFA:0001374 atrial myocardium atrial myocardium cardiac muscle cell increased amount , abnormal
atrial myocardium cardiac muscle cell decreased mass density , abnormal
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0005035 subintestinal vein subintestinal vein collapsed , abnormal
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 ZFA:0005061 ventricular myocardium ventricular myocardium cardiac muscle cell increased amount , abnormal
ventricular myocardium cardiac muscle cell increased mass density , abnormal
Show

 ZFA:0005309 pronephric glomerular capillary pronephric glomerular capillary absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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